Leadership & Faculty

Translational Data Science Integrated Research Center

Leadership & Faculty

The Translational Data Science Integrated Research Center connects computational and quantitative scientists to biologists, clinicians and experimentalists.

Dr. Raphael Gottardo

Dr. Raphael Gottardo

Scientific Director, TDS IRC
Dr. Raphael Gottardo oversees the TDS IRC's vision and direction. Dr. Gottardo’s leadership helps position Fred Hutch as an incubator for new computational tools and methodologies and as a translator of data-driven discoveries into improved patient care.

Faculty Profile


TDS IRC Faculty

Alphabetical Listing:

Select a letter to display a list of Faculty members
A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z  [Show All]
Assistant Member, Clinical Research Division
Research Assistant Professor of Medical Oncology, University of Washington School of Medicine
Retrovirus-based gene transfer into hematopoietic stem cells has emerged as a viable treatment for genetic, malignant and infectious diseases with the potential to significantly decrease global disease burden.
Phone: (206) 667-7110
Fax: (206) 667-6124
Research Assistant Professor, Pharmaceutical Outcomes Research & Policy Program, Department of Pharmacy, University of Washington
Joint Assistant Member, HICOR, Public Health Sciences Division
Research is focused on health outcomes and survival analysis, development and evaluation of biomarkers and predictive models
Phone: (206) 685-9658
Fax: (206) 543-3835
Characterizes virus diversity, evolution, circulation patterns. Identifies epidemiological patterns from sequence data and develops methods to predict evolutionary growth or decay across strains.
Phone: (206) 667-6372
Assistant Member, Human Biology Division
The goal of the Berger laboratory is to enable precision medicine by systematically uncovering the molecular alterations in cancer, determining the function of these variant alleles, and understanding how these alleles modulate response to targeted or immune-based therapies.
Phone: (206) 667-6281
The Bielas Laboratory studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the pathogenesis of cancer and age-related disease.
Phone: (206) 667-3170
Fax: (206) 667-2537
Senior Vice President and Director, Basic Sciences Division
Howard Hughes Medical Institute Investigator, Howard Hughes Medical Institute
Chromosome segregation and checkpoints
Phone: (206) 667-1351
Fax: (206) 667-6526
Associate Member, Basic Sciences Division
Howard Hughes Medical Institute Investigator, Howard Hughes Medical Institute
Molecular evolution of viruses and proteins
Phone: (206) 667-3622
Fax: (206) 667-6525
Phone: (206) 667-7041
Fax: (206) 667-1319
Associate Member, Basic Sciences Division
Alternative splicing and RNA processing
Phone: (206) 667-5662
Fax: (206) 667-1319
Research Professor, Biostatistics, University of Washington
Graduate Faculty, Biostatistics, University of Washington
PI, Statistical and Data Management Center, Microbicide Trials Network
Design and analysis of trials for HIV prevention, joint models for longitudinal and survival data and statistical methods in HIV/AIDS and cardiovascular research.
Phone: (206) 667-1731
Fax: (206) 667-4812
Affiliate Professor, Biostatistics, University of Washington
Research focus includes the development of statistical methods for analysis of survival and longitudinal data from clinical trials and epidemiological studies.
Phone: (206) 667-7051
Fax: (206) 667-4378
Executive Vice President and Deputy Director, Fred Hutchinson Cancer Research Center
Professor, Department of Medicine, University of Washington
Rosput Reynolds Endowed Chair, Fred Hutchinson Cancer Research Center
The Clurman Lab studies how cell division is regulated in normal cells, and how abnormal control of cell division leads to cancer. They hope to use these mechanistic insights into tumor formation to develop new cancer treatment strategies.
Phone: (206) 667-4524
Fax: (206) 667-5255
Affiliate Assistant Professor, Biostatistics, University of Washington
Research focus: Statistical methods in HIV prevention trials and in genetic association studies.
Phone: (206) 667-6364
Fax: (206) 667-4378
Senior Vice President, Director and Full Member, Clinical Research Division, Fred Hutchinson Cancer Research Center
President and Executive Director, Seattle Cancer Care Alliance
Head, Department of Medicine, Division of Medical Oncology, University of Washington
Past President, 2016-2017, American Association for Cancer Research
Past President, 2007-2008, American Society Clinical Oncology
Nancy Davidson is the vice president and director of Fred Hutch's Clinical Research Division and President and Executive Director of the Seattle Cancer Care alliance.
Research focus include clinical trial design; clinical trials data management in international settings, group and cluster randomized; analysis of sexual risk; and mediator analysis
Phone: (206) 667-5661
Fax: (206) 667-4378
Transcription networks regulating proliferation and differentiation
Phone: (206) 667-4445
Fax: (206) 667-6522
Chair, Strategic Advisors Committee, Hutch Data Commonwealth
Research focuses on statistical and computer modeling for policy development. A critical component of this work is the estimation of disease natural history and progression which then forms a substrate for modeling comparative effectiveness of alternative interventions.
Phone: (206) 667-6561
Fax: (206) 667-7264
Co-Program Head, Biostatistics Program
Biostatistician with extensive experience in biomarker evaluation for cancer risk assessment, early detection, diagnosis, and prognosis.
Phone: (206) 667-6038
Fax: (206) 667-5964
Affiliate Associate Professor, Biostatistics, University of Washington
Principal Investigator, Fong Group
Statistical problems in biological assays, Biological sequence analysis, Stochastic optimization
Phone: (206) 667-1093
Fax: (206) 667-4378
Professor, Medicine, University of Washington
Adjunct Associate Professor, Microbiology, University of Washington
Director, Infectious Diseases Fellowship Training Program, University of Washington
Determining how changes in microbial communities impact human health; identifying, characterizing, and culturing microbes found in the human genital tract; and associating the reproductive tract microbiome with human disease. Developing molecular diagnostic tests to detect and identify pathogens in immunocompromised hosts such as cancer patients.
Phone: (206) 667-1935
Fax: (206) 667-4411
Paul Stephanus Memorial Endowed Chair, Fred Hutchinson Cancer Research Center
The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.
Phone: (206) 667-4500
Fax: (206) 667-5815
Assistant Member, Human Biology Division
Dr. Ghajar directs the Laboratory for the Study of Metastatic Microenvironments (LSM2). The goal of his research program is to understand how microenvironments within distant tissues regulate dormancy and growth of disseminated tumor cells (DTCs), and whether these niches convey chemoresistance to dormant DTCs. His belief is that solving these puzzles will allow the development of therapeutic regimens that eradicate dormant DTCs before they can develop into full-blown metastases.
Phone: (206) 667-7080
Fax: (206) 667-2537
Principal Investigator, Statistical Data Management Center, HIV Vaccine Trials Network
Research Professor, Biostatistics, University of Washington
Graduate Faculty, Biostatistics, University of Washington
Research focus includes vaccine clinical trials, the design and analysis of Phase I/II trials, for evaluating vaccine effects on immune responses; the design and analysis of Phase 2b/III trials, for evaluating vaccine efficacy, immune correlates, sieve analysis, and post-infection vaccine effects; general biostatistical methods research, such as survival analysis, causal inference, and evaluation of surrogate endpoints
Phone: (206) 667-7299
Fax: (206) 667-4812
Scientific Director, Translational Data Science Integrated Research Center, Fred Hutchinson Cancer Research Center
J. Orin Edson Foundation Endowed Chair, Fred Hutchinson Cancer Research Center
Affiliate Professor, Statistics, University of Washington
Developing methods and tools for high-throughput, high-dimensional experiments with applications in vaccine research, immunology and immunotherapy; flow cytometry, peptide microarrays, next generation sequencing; Bayesian inference and computation and statistical computing
Phone: (206) 667-4076
Fax: (206) 667-4378
Assistant Member, Computational Biology Program, Public Health Sciences Division
The Ha laboratory is interested in studying the role of genomic alterations in cancer progression and using this knowledge to expand applications for precision medicine.
Phone: (206) 667-2802
Fax: (206) 667-1319
Assistant Member, Pediatric Oncology and Stem Cell and Gene Therapy Programs, Integrated Immunotherapy Research Center, Clinical Research Division
Research is focused on understanding the factors that control the formation of the hematopoietic stem cells, harnessing technologies to analyze gene activities across the many different cell types within the special hematopoietic stem cell niche and identifying specific biological signals that trigger the formation of blood stem cells to develop a system for generating and cultivating blood stem cells in the lab.
Phone: (206) 667-1095
Fax: (206) 667-6084
Professor, Biostatistics, University of Washington
Adjunct Professor, Applied Mathematics and Epidemiology, University of Washington
Director and Founder, Summer Institute in Statistics and Modeling in Infectious Diseases, University of Washington
Research focus included the design and evaluation of vaccine field trials; modeling infectious disease dynamics and strategies for mitigation and control; causal inference in infectious diseases; and evaluating surrogates of protection.
Phone: (206) 667-2722
Fax: (206) 667-4378
Assistant Professor of Genome Sciences, Genome Sciences, Assistant Professor of Genome Sciences
Joint Assistant Member, Computational Biology Program, Public Health Sciences Division
Uses population genetic theory and high-throughput biological sequence analysis to study recent evolutionary history in humans and other species. A primary research interest is the evolution of mutagenesis, understanding the forces that control DNA replication fidelity, the mutational breakdown of established traits, and the ultimate origin of new traits.
Phone: (206) 616-9581
Fax: (206) 667-1319
Howard Hughes Medical Institute Investigator, Howard Hughes Medical Institute
Chromosome structure and function
Phone: (206) 667-4515
Fax: (206) 667-5889
Assistant Member, Clinical Research Division
Attending Physician, SCCA Infectious Disease Service , Seattle Cancer Care Alliance
Assistant Professor, University of Washington
Clinical and translational investigations relating to infections in immunocompromised hosts, with a focus on disease associations, risk stratification, and diagnostic strategies for viral infections in transplant recipients
Phone: (206) 667-6504
Fax: (206) 667-4411
Affiliate Professor, University of Washington
Research focus: Statistical genomics, GWAS.
Phone: (206) 667-2854
Fax: (206) 667-7004
Affiliate Associate Professor, Biostatistics, University of Washington
Statistical methods in biomarker evaluation for disease screening, surrogate endpoint identification, and treatment selection; genome-wide association studies and causal inference
Phone: (206) 667-4198
Fax: (206) 667-4378
Research focus includes statistical methods for bioassays (e.g., flow cytometry, sequencing); dynamic modeling of biological systems (e.g., multi-type cell populations, B-cell repertoire); nonparametric methods for supervised and unsupervised learning; stochastic processes (e.g., branching processes); algorithms for scalable data analysis.
Phone: (206) 667-2809
Fax: (206) 667-4378
Affiliate Associate Professor, Biostatistics, University of Washington
Graduate Faculty, Biostatistics, University of Washington
Clinical trials methodology; Vaccine evaluation; biomarker that predict an individual’s response to a given treatment and statistical analyses of vaccine trial data
Phone: (206) 667-6353
Fax: (206) 667-4378
The Kemp Lab seeks to identify the next generation of targeted anticancer agents. We use a combination of high throughput functional genomic and small molecule screens, and genomic analysis applied to a range of isogenic and patient derived tumor models. We are discovering and validating novel drug targets and therapeutic options for multiple solid tumor types including pancreatic, ovarian, head and neck and breast cancer.
Phone: (206) 667-4252
Fax: (206) 667-5815
Stephanus Family Endowed Chair for Cell and Gene Therapy, Clinical Research Division
Director, Stem Cell and Gene Therapy Program, Clinical Research Division
Associate Head of Transplantation Biology, Clinical Research Division
The Kiem Lab is focused on research and clinical trials using stem cell biology and stem cell gene transfer with the goal of developing stem cell-based treatment strategies for patients with genetic or infectious stem cells. We are conducting studies using embryonic stem cells and induced pluripotent stem cells.
Phone: (206) 667-4409
Fax: (206) 667-6124
Member and Program Head, Biostatistics Program, Public Health Sciences Division
Research expertise is adaptive function estimation for genomic data and nonparametric function estimation and the analysis of high dimensional data, in particular as applied to genomic and proteomics data.
Phone: (206) 667-7808
Fax: (206) 667-4142
Member, Biostatistics Program, Public Health Sciences Division
Group Statistician and Director of Statistical Center, Southwest Oncology Group (SWOG)
Statistical methods for clinical trials, adaptive and non-parametric regression models, survival analysis.
Phone: (206) 667-6089
Fax: (206) 667-4408
Assistant Member, Human Biology Division
The primary goal of the research is to identify vulnerabilities for therapeutic exploitation to enhance and extend life for patients with late-stage prostate cancer.
Phone: (206) 667-6819
Fax: (206) 667-4023
Assistant Professor, Department of Epidemiology, University of Washington
Genetic Epidemiology, cancer, cardiovascular disease, genome-wide association studies, gene-environment interactions
Phone: (206) 221-3148
Fax: (206) 667-4787
Phone: (206) 667-4282
Fax: (206) 667-7004
Estimation and inference from high-dimensional data, in particular to develop statistical machine learning methods to understand biological processes in genomics and metagenomics.
Phone: (206) 667-2897
Fax: (206) 667-7004
Associate Member, Human Biology Division
The MacPherson Lab is focused on understanding the mechanisms through which cancer-mutated genes drive tumorigenesis. The lab studies small cell lung cancer and other solid tumors. We generate novel genetically engineered mouse models that we use to interrogate the biology underlying major cancer driver genes. We are particularly interested in understanding epigenetic regulators that are genetically mutated in human tumors.
Phone: (206) 667-6464
Fax: (206) 667-2917
Phone: (206) 667-7318
Fax: (206) 667-1319
Research focuses on development and application of novel methods for identifying and characterizing antigen specific T cells in the context of cancer and chronic infection with the goal of identifying specific and accurate biomarkers of human health and disease based on antigen-specific T cells.
Phone: (206)667-2807
Fax: (206) 667-7711
Research focus: Survival analysis, cure modeling, change-point problems, longitudinal and multivariate data analysis
Phone: (206) 667-5749
Fax: (206) 667-7004
Member and Associate Director, Public Health Sciences Division
Cancer Prevention Program, Public Health Sciences Division
Fred Hutch 40th Anniversary Endowed Chair, Fred Hutchinson Cancer Research Center
Genetic and molecular epidemiology, common complex diseases, including cancer, obesity, type 2 diabetes and cardiovascular diseases, as well as intermediate traits, including inflammation and metabolic measurements.
Phone: (206) 667-2450
Fax: (206) 667-7850
Member, Program in Immunology, Clinical Research Division
Scientific Director, Immunopathology Lab, Clinical Research Division
Mechanisms of tumor-induced immune tolerance by which tumors can escape anti-tumor immune responses, including natural and therapy-induced responses
Phone: (206) 667-6648
Fax: (206) 667-7983
Associate Member, Clinical Research Division
Associate Member, Biostatistics Program, Public Health Sciences Division
Research focus: Methods for the analysis of high-dimensional, longitudinal and functional data, including array, spectral, image and network-based data.
Phone: (206) 667-1079
Fax: (206) 667-7004
Member, Clinical Research Division, Program in Immunology, Program in Immunology
Professor, School of Medicine, University of Washington
Attending Physician, Seattle Cancer Care Alliance
Studies focus on 1) understanding the roles of distinct T cell subsets in protective immunity to pathogens and tumors and on 2) the development and clinical application of adoptive T cell therapies for viral diseases and cancers, using unmodified and genetically modified antigen-specific T cells.
Phone: (206) 667-7791
Fax: (206) 667-7983
Affiliate Member, Basic Sciences Division
Dr. Penny E. Petersen Memorial Chair for Lymphoma Research, Fred Hutchinson Cancer Research Center
Director of Molecular and Cellular Biology (MCB) Graduate Program, Fred Hutchinson Cancer Research Center
The Salama lab studies the gastric bacterial pathogen Helicobacter pylori, which infects half the world's population and can cause ulcers and gastric cancer.
Phone: (206) 667-1540
Fax: (206) 667-6524
Associate Member, Clinical Research Division
Associate Professor, Department of Medicine, University of Washington
Attending Physician, SCCA Infectious Consulting Service, Seattle Cancer Care Alliance
Interest in describing the quantitative and dynamical features of human pathogens and immune responses. Most of work to-date is on the pathogenesis of HSV-2 infection but also interested in applying models to optimize viral eradication strategies, and to use models to capture kinetic features of the human microbiome.
Structural molecular immunology and vaccinology: using biophysical approaches to study proteins and interactions mediating or modulating adaptive and innate immune responses
Phone: (206) 667-5587
Fax: (206) 667-5939
Assistant Member, Basic Sciences Division
Regulation of mRNA translation
Phone: (206) 667-4679
Develops statistical/computational methods and software packages for different types of omic data, including array or sequencing data for germline/somatic point mutations, copy number alterations, DNA methylation, and gene expression.
Phone: (206) 667-3188
Fax: (206) 667-7004
The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.
Phone: (206) 667-4499
Fax: (206) 667-6524
Associate Member, Clinical Research Division
Attending Physician, Seattle Cancer Care Alliance
Adoptive T cell therapy for hematologic malignancies and in investigating the immunologic perturbations in hematopoietic stem cell transplantation
Phone: (206) 667-7073
Fax: (206) 667-7983
Deputy Head, Global Oncology
Associate Member, Clinical Research Division
Associate Professor of Medicine, University of Washington School of Medicine
Major research interests are the pathogenesis and management of viral-associated malignancies, including cancers that occur in the setting of HIV.
Phone: (206) 667-7585
Fax: (206) 667-1965
Assistant Member, Cancer Prevention Program, Public Health Sciences Division
Cancer care delivery research including, including comparative effectiveness, health care delivery, health disparities, and health outcomes, and in particular the utilization of large registry and administrative claims databases in conjunction with clinical trial data for secondary data analysis.
Phone: (206) 667-2860
Fax: (206) 667-4408
Member, Program in Immunology, Clinical Research Division
Professor of Medicine, Department of Medicine, University of Washington
Attending Physician, Seattle Cancer Care Alliance
Program Head, Global Oncology, Global Oncology
Clinical focus is treating patients with blood cancers such as leukemia, lymphoma, and multiple myeloma. Research is focused on cancer immunology, specifically the mechanisms and molecules that mediate graft-versus-host disease and graft-versus tumor.
Phone: (206) 667-6441
Fax: (206) 667-7983
Assistant Member, Clinical Research Division
Clinical trial design, modeling and statistical analyses of biomarkers, genetics and patient outcomes
Phone: (206) 667-3358
Fax: (206) 667-6358
Researcher silhouette
Research focus: Estimating equation techniques, developing statistical methods for assessing genetic associations, gene-environment interactions including methods for haplotype-based methods, genome-wide association studies, time-varying phenotypes and sequence analysis
Phone: (206) 667-6927
Fax: (206) 667-2437
Associate Member, Biostatistics Program
Statistical methods for personalized medicine, dynamic treatment regimes and survival analysis using data from both clinical trials and complex observational studies.
Phone: (206) 667-6752
Fax: (206) 667-4408
Research focus: Statistical methods for evaluating the ability of biomarkers or algorithms to identify cancer early, or signal disease prognosis; Statistical methods for family-based association studies
Phone: (206) 667-7580
Fax: (206) 667-5977