Northwestern University, Evanston, IL, 1965, BS
Northwester Medical School, Chicago, IL, 1969, MD
UCLA Medical Center, Los Angeles, CA, 1973-1974, Residency
University of Washington, Division of Gastroenterology, Seattle, WA, 1973-1974, Senior Resident
Boston University Medical Center, Boston, MA, 1975-1976, Clinical Renal Fellow
Peter Bent Brigham Hospital, Boston, MA, 1976-1977, Research Fellow (Nephrology/Pathology)
The Zager laboratory studies mechanisms and adaptive cellular responses to ischemic and toxic kidney injury. The three areas of particular interest are as follows:
- Mechanisms by which injured cells become resistant to superimposed ischemic or toxic attack. In particular, alterations in plasma membrane lipid homeostasis, stress protein induction, including proteins that are not normally produced in kidney, are addressed. Albumin, hemopexin, haptoglobin and alpha one antitrypsin are some prominent examples.
- Mechanisms by which the post injured kidney develops hyper-responsive to Toll like receptor ligands are studied. In particular, epigenetic remodeling is addressed.
- Exploration of novel therapeutic strategies to mitigate progressive renal injury to chronic renal disease are explored. A notable example is testing the role of novel recombinant heme oxygenase proteins as prophylactic agents to prevent acute renal failure.
Studies that address the above research projects are ongoing.