Anton M. Sholukh, PhD

Anton M. Sholukh, PhD

Senior Staff Scientist, Corey Lab
Vaccine and Infectious Disease Division

Education

National Academy of Sciences of Belarus, 2002, PhD (Biochemistry)
Belarus State University, 1993, MS (Biology, Biochemistry)
Belarus State University, 1991, BS (Biology)

Research Focus

Current Research Projects

  • Analysis of humoral immune responses to HSV-2 and HSV-2 vaccine candidates
  • Understanding the role of tissue B cells in HSV-2 infection

Research Interests

  • Understanding the role of different antibody isotypes in protection against viral infections
  • Studying functions of tissue-resident B cells and mechanisms driving B cell tissue homing
  • The role of T-cell help in the “quality” of protective B-cell response
  • Development of novel non-vaccine approaches to prevent mucosal viral infections
  • Vaccine design

Selected Publications

Sholukh AM*, Watkins JD*, Vyas HK*, Gupta S, Lakhashe SK, Thorat S, Zhou M, Hemashettar G, Bachler BC, Forthal DN, Villinger F, Sattentau QJ, Weiss RA, Agatic G, Corti D, Lanzavecchia A, Heeney JL, Ruprecht RM.  Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge. Vaccine 2015; 33(17): 2086-95. *equal contribution.

Sholukh AM, Byrareddy SN, Shanmuganathan V, Hemashettar G, Lakhashe SK, Rasmussen RA, Watkins JD, Vyas HK, Thorat S, Brandstoetter T, Mukhtar MM, Yoon JK, Novembre FJ, Villinger F, Landucci G, Forthal DN, Ratcliffe S, Tuero I, Robert-Guroff M, Polonis VR, Bilska M, Montefiori DC, Johnson WE, Ertl HC, Ruprecht RM.  Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose. Retrovirology 2014; 11:8. PMCID: 3905655.

Watkins JD, Sholukh  AM, Mukhtar MM, Siddappa NB, Kim M, Reinherz EL, Gupta S, Forthal DN, Heeney JL, Sattentau Q, Weiss RA, Villinger F, Corti D, Lanzavecchia A, Ruprecht RM  and CAVD Project Group.  Anti-HIV IgA Isotypes: Differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission. AIDS 2013; 27(9). F13-F20.

Sholukh AM*, Mukhtar MM*, Humbert M, Essono SS, Watkins JD, Vyas HK, Shanmuganathan V, Hemashettar G, Kahn M, Hu SL, Montefiori DC, Polonis VR, Schur PH, Ruprecht RM.  Isolation of monoclonal antibodies with predetermined conformational epitope specificity. PLoS ONE 2012; 7(6): e38943. *equal contribution.

Watkins JD, Siddappa NB, Lakhashe SK, Humbert M, Sholukh A, Hemashettar G, Wong YL, Yoon JK, Wang W, Novembre FJ, Villinger F, Ibegbu C, Patel K, Corti D, Agatic G, Vanzetta F, Bianchi S, Heeney JL, Sallusto F, Lanzavecchia A, Ruprecht RM.  An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV. PLoS ONE 2011; 6(3): e18207. 



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Anton M. Sholukh, PhD

Contact Information

Phone
(206) 667-5503
Fax
(206) 667-4411
Email
Additional contact

Mail Stop: E5-110