Martin Prlic, PhD

Martin Prlic, PhD

Affiliate Associate Professor, Department of Global Health
University of Washington
Faculty Member, Interdisciplinary Program in Pathobiology
University of Washington
Faculty Member, Molecular & Cellular Biology Program
Fred Hutch & University of Washington


University of Minnesota, 2004, PhD (Immunology, Microbiology, Cancer Biology and Immunology Program)
University of Salzburg, 1999, MS (Genetics)

Research Interests

  • Studying T cell, innate-like T cell and NK cell responses in context of infections, vaccines and cancer
  • Manipulating T cell, innate-like T cell and NK cell responses for therapeutic purposes (incl. infections, vaccines and cancer)
  • Mucosal immunity
  • Single-cell analysis approaches 

Selected Publications

Voillet V, Buggert M, Slichter CK, Berkson JD, Mair F, Addison MM, Dori Y, Nadolski G, Itkin MG, Gottardo R, Betts MR and Prlic M
Human MAIT cells exit peripheral tissues and re-circulate via lymph in steady state conditions (in press)

Mair F and Prlic M
28-color immunophenotyping of the human dendritic cell compartment Cytometry (advanced online Jan 2018) doi:10.1002/cyto.a.23331

Mpina M, Maurice NJ, Yajima M, Slichter CK, Miller HW, Dutta M, McElrath MJ, Stuart KD, De Rosa SC, McNevin JP, Linsley PS, Abdulla S, Tanner M, Hoffman SL, Gottardo R, Daubenberger CA, Prlic M.
Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations. J Immunol. 2017 Jul 1;199(1):107-118

Slichter CK, Miller HW, McDavid A, Finak G, Seymour BJ, McNevin JP, Diaz G, Czartoski JL, McElrath MJ, Gottardo R and Prlic M.
Distinct activation thresholds of human conventional and innate-like memory T-cells. JCI Insight. 2016;1(8):e86292.

Zehn D, Roepke S, Weakly K, Bevan MJ, Prlic M.
Inflammation and TCR signal strength determine the breadth of the T cell response in a bim-dependent manner. J Immunol 192(1):200-205, 2014 [PMCID: PMC3903384].

Chu T, Tyznik AJ, †Roepke S, Berkley A, Woodward-Davis A, Pattacini L, Bevan MJ, Zehn D, Prlic M.
Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner. Cell Rep 3(3):701-708, 2013 [PMCID: PMC3628815].

Awards and Honors:

2004 Veneziale-Steer Award
2005 Leukemia and Lymphoma Society Fellow Award
2008 Theodor Körner Award
2008 Leukemia and Lymphoma Society Special Fellow Award
2009 NIH Pathway to Independence Award (K99/R00)
2009 American Association of Immunologists (AAI) – Invitrogen Trainee Achievement Award
2012 NIH Director’s New Innovator Award

Current Projects

  • Bystander-activation of memory T cells and subsequent effects on host immunity
  • Human mucosal-associated invariant T (MAIT) cells in health and disease
  • Mucosal immunity in response to infections, cancer and other inflammatory diseases

Additional Links & Information

Related Labs & Projects

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Martin Prlic, PhD

Contact Information

(206) 667-2216
(206) 667-2209
Additional contact

Mail Stop E5-110