Holly Janes, PhD

Holly Janes, PhD

Affiliate Associate Professor, Biostatistics
University of Washington
Graduate Faculty, Biostatistics
University of Washington


University of Washington, 2005, PhD (Biostatistics)
University of Massachusetts, 2000, MS (Mathematics)
Skidmore College, 1998, BA (Philosophy of Physical Science and Mathematical Modeling)

Research Interests

  • HIV vaccine development
  • Vaccine evaluation
  • Clinical trial design
  • Biomarker evaluation

Awards and Honors

2008, Travel Award, Global HIV Vaccine Enterprise, AIDS Vaccine Conference
2006, Young Investigator Award, Section on Statistics in Epidemiology, American Statistical Association
2005, Gilbert S. Omenn Graduate Student Award for Academic Excellence, School of Public Health, University of Washington
2005, Student Conference Award, International Society for Clinical Biostatistics
2005, Senior Student Award, Department of Biostatistics, University of Washington
2004, Student Paper Award, Section on Statistics and the Environment, American Statistical Association
2000, Cardiovascular Biostatistics Training Grant, National Institutes of Health

Selected Publications

Fong Y, Shen X, Ashley VC, Seaton KE, Yu C, Grant SP, Ferrari G, deCamp AC, Bailer RT, Koup RA, Montefiori D, Haynes BF, Sarzotti-Kelsoe M, Graham BS, Carpp LN, Hammer SM, Sobieszczyk M, Karuna S, Swann E, DeJesus E, Mulligan M, Frank I, Buchbinder S, Novak RM, McElrath MJ, Kalams S, Keefer M, Frahm NA, Janes H, Gilbert PB, Tomaras GD.   Vaccine-induced antibody responses modify the association between T-cell immune responses and HIV-1 infection risk in HVTN 505. The Journal of Infectious Diseases 2018. 217.10.1093/infdis/jiy008. 

Janes H, Corey L, Ramjee G, Carpp L, Lombard L, Cohen M, Gilbert P, Gray G.  Weighing the evidence of efficacy of oral PrEP for HIV prevention in women in southern Africa.  AIDS Res Human Retroviruses 2018 https://doi.org/10.1089/AID.2018.0031 [Epub ahead of print].

Janes H, Cohen K, Frahm N, DeRosa S, Sanchez B, Hural J, Magaret C, Karuna C, Bentley R, Gottardo G, Finak G, Grove D, Shen M, Graham B, Koup R, Mulligan M, Koblin B, Buchbinder S, Keefer M, Adams E, Anude C, Corey L, Sobieszczyk M, Hammer S, Gilbert PB, McElrath MJ.  Higher T cell responses induced by DNA/rAd5 HIV-1 preventative vaccine are associated with lower HIV-1 infection risk in an efficacy trial. J Infec Dis. 2017 215(9):1376-1385. PMCID: 5853653

Janes H, Tovanabutra S, Herbeck JT, Frahm N, Duerr A, Hural J, Corey L, Self SG, Buchbinder S, McElrath JM, O'Connell RJ, Paris R, Rerks-Ngarm S, Nitayaphan S, Pitisuttihum P, Kaewkungwal J, Robb ML, Michael NM, Mullins JI, Kim JH, Gilbert PB, Rolland M. HIV-1 infections with multiple founders are associated with higher viral loads. Nat Med. 2015;21(10):1139-41. PMCID: 4598284.

Janes H, Pepe MS, McShane LM, Sargent DJ, Heagerty PJ. The fundamental difficulty with evaluating the accuracy of biomarkers for guiding treatment.  J Nat Cancer Inst. 2015;107(8): pii: djv157. PMCID: 4609557.

Hammer SM, Sobieszczyk ME, Janes H, Karuna ST, Mulligan MJ, Grove D, Koblin BA, Buchbinder SP, Keefer MC, Tomaras GD, Frahm N, Hural J, Anude C, Graham BS, Enama ME, Adams E, DeJesus E, Novak RM, Frank I, Bentley C, Ramirez S, Fu R, Koup RA, Mascola JR, Nabel GJ, Montefiori DC, Kublin J, McElrath MJ, Corey L, Gilbert PB, HVTN 505 Study Team. Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine. N Engl J Med. 2013;369(22):2083-92. PMCID: 4030634.

Janes H, Gilbert P, Buchbinder S, Kublin J, Sobieszczyk ME, Hammer SM. In Pursuit of an HIV Vaccine: Designing Efficacy Trials in the Context of Partially Effective Non-Vaccine Prevention Modalities. AIDS research and human retroviruses. 2013;29(11):1513-23. PMCID: 3809388.

Haynes BF, Gilbert PB, McElrath MJ, Zolla-Pazner S, Tomaras GD, Alam SM, Evans DT, Montefiori DC, Karnasuta C, Sutthent R, Liao HX, DeVico AL, Lewis GK, Williams C, Pinter A, Fong Y, Janes H, DeCamp A, Huang Y, Rao M, Billings E, Karasavvas N, Robb ML, Ngauy V, de Souza MS, Paris R, Ferrari G, Bailer RT, Soderberg KA, Andrews C, Berman PW, Frahm N, De Rosa SC, Alpert MD, Yates NL, Shen X, Koup RA, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Rerks-Ngarm S, Michael NL, Kim JH. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. The N Engl J Med. 2012;366(14):1275-86. PMCID: 3371689.

Janes H, Pepe MS, Bossuyt PM, Barlow WE. Measuring the performance of markers for guiding treatment decisions. Ann Intern Med. 2011;154(4):253-9. PMCID: 3085402.

Janes H, Pepe MS. Matching in studies of classification accuracy: Implications for analysis, efficiency, and assessment of incremental value. Biometrics. 2008;64(1):1-9.

Holly Janes, PhD

Contact Information

(206) 667-6353
(206) 667-4378
Additional contact

Mail Stop M2-C200