Endowed Chair for Breast Cancer Research
Fred Hutchinson Cancer Research Center
Wellesley College, BA Molecular Biology
Harvard Medical School, MD
Hospital of the University of Pennsylvania, Internal medicine internship
Johns Hopkins Hospital, Internal medicine residency
National Cancer Institute, Medical oncology fellowship
My laboratory focus has been on the role of epigenetics in breast cancer, especially the role of aberrant DNA methylation and histone modifications in hormone resistance using human breast cancer cell lines as a model system. These preclinical studies have advanced to early phase clinical trials assessing the role of epigenetic modifiers for treatment of breast cancer. Through my role as a member and chair of the Breast Committee for the Eastern Cooperative Oncology Group I have served as a co-investigator or lead investigator for a number of practice-changing breast cancer trials. These include trials of optimal endocrine therapy for premenopausal hormone-responsive breast cancer, optimization of endocrine therapy for postmenopausal women, use of taxanes in the adjuvant setting, and utility of trastuzumab for early HER-2 positive breast cancer. As a founder of the Translational Breast Cancer Research Consortium (TBCRC) I have contributed to the development of early phase biospecimen-rich translational trials in breast cancer. I am an active participant in the development of evidence-based clinical pathways in breast cancer treatment and helped to spearhead a focus on value of cancer care through the American Society of Clinical Oncology.
Management of breast cancer and conduct of all phases of oncology clinical trials
Dr. Nancy Davidson, Senior Vice President of the Clinical Research Division at the Fred Hutchinson Cancer Research Center, explains the complimentary relationship of patient care and team science in cancer research.