Translational Research Program

Gut Microbiota and Colonic Gene Expression: A Lignan Trial in Humans

PD/PI: Johanna Lampe & Hullar & Chapkin (Texas A & M)                            

We will use an intervention study in humans to test the effect of lignan-rich flaxseed meal and a lignan extract on colonic mucosal mRNA expression, and to evaluate the modifying effect of gut microbial community on the response.  In-vitro models also will be used to investigate genes involved in the biotransformation of lignans by the human gut microbiota.