collage of women eligible to participate

Millions of women are bothered by postmenopausal vaginal symptoms, including dryness and pain with sex. Are you one of them?

After menopause, up to 50 percent of women have vaginal problems such as dryness, itching, irritation, burning, or pain with sexual activity. Despite the large number of women affected, very little is known about how standard treatments for vaginal symptoms compare or how they affect underlying biological causes of vaginal problems.

Researchers at Fred Hutchinson Cancer Research Center, the University of Minnesota and Group Health Research Institute are doing a study funded by the National Institute on Aging. The purpose of our study is to learn more about vaginal symptoms as women age and compare two popular treatments for symptom relief — a vaginal moisturizer and a low dose estrogen tablet that is placed in the vagina.

Our goal is to improve knowledge that will help to relieve vaginal symptoms, a much overlooked area of women’s health. We are seeking 300 women to help us with a 12-week study.


Enrollment Closed

  • If you are interested in enrolling, contact us at
  • Include your name and phone number and we will call you.
  • There is  no obligation to participate.

You can help us evaluate treatments to relieve women's symptoms and learn more about vaginal health as women age.

Study participation includes:

  • You will be asked to come to 3 clinic visits over 12 weeks.
  • You will be asked to fill out questionnaires and symptom diaries at home.
  • You will be asked to use both vaginal tablets and vaginal gel for 12 weeks.
  • Each clinic visit will involve a physical exam done by our study nurse or doctor, including a pelvic exam.
  • To thank you for being in the study you would receive between $150-300 if you finish all study
  • Live in the Seattle and Minneapolis or
  • Women aged 45-70 years
  • Periods stopped more than 2 years ago
  • You have bothersome vaginal symptoms such as dryness, itching, burning or pain

You will not be eligible for the study if:

If you have any of the following health conditions.

  • Current unexplained abnormal vaginal bleeding
  • Pelvic or vaginal surgery in prior 60 days
  • Current cancer treatment
  • Current or past thromboembolic disease (pulmonary embolus or deep vein thrombosis,
    not including thrombophlebitis), heart attack, or stroke
  • Current severe liver disease
  • Current or past breast or endometrial cancer or pre-cancer

If you are taking the following medications.

  • Hormonal contraceptives
  • Tamoxifen
  • Evista
  • Ospemifene