Epidemiology Program

Geographic Clustering of Myelodysplastic Syndromes (MDS) and Correlation with Pollution Sources

Principal Investigator: Anneclaire De Roos

This study constitutes one of the first large population-based investigations of incidence patterns of myelodysplastic syndromes (MDS) in the United States. We are looking for evidence of space-time clustering of MDS, which may be informative regarding a potential infectious origin of MDS, or the possible etiologic role of environmental exposures. Space-time clustering of incident MDS in the Seattle-Puget Sound region of the Surveillance, Epidemiology, and End Results (SEER) program will be evaluated using a spatial scan statistic (cases only) and a nearest-neighbor approach (cases compared to other-cancer controls). We will also study potential environmental causes of incident MDS by analyzing residential proximity to pollution sources including industrial facilities and traffic. It is expected that findings from this study will generate hypotheses to direct future, more in-depth, etiologic studies of MDS.