Epidemiology Program

Residential Proximity to Industrial Facilities and Risk of Non-Hodgkin Lymphoma

Principal Investigator: Anneclaire De Roos

The incidence of NHL increased in the latter half of the 20th century, spurring interest in environmental factors as potential causes. In this case-control study we are investigating long-term environmental exposure to industrial pollutants as a risk factor for NHL, among 1321 cases and 1057 controls recruited in California, Washington, Iowa, and Michigan. This project requires development of an extensive exposure geodatabase of current and historical industry locations, census data, and wind patterns. Sources of data on industries include the Environmental Protection Agency’s Risk-Screening Environmental Indicators (RSEI) database of Toxics Release Inventory data, and historical business directory listings from Dunn & Bradstreet. Exposure is evaluated for each participant by measuring distances between study participant residential locations and industry locations/modeled emissions, with summary exposure metrics averaged over a 30-year exposure period of interest.