Breast Cancer Risk and Molecular Change After Chernobyl This study has two primary aims: 1) to investigate whether the risk of premenopausal breast cancer is associated with individual radiation dose to the breast from the Chernobyl accident, to estimate the risk per unit dose, to investigate the shape of the dose- response, and potential dose effect modifying factors, including molecular characteristics and established breast cancer risk factors; and 2) to investigate whether the association of breast cancer risk with radiation exposure differs according to characteristics of breast cancer, including hormone receptor status, genomic loss and gain, and specific alterations in 14 selected DMA repair genes.
Cancer Surveillance System The Cancer Surveillance System (CSS) collects population-based data on cancer incidence and survival in 13 counties in western Washington State. These cancer data are collected to provide public health scientists and practitioners with the ability to track trends in the incidence of all forms of cancer (surveillance); identify and investigate patterns of cancer occurrence (epidemiology); and monitor of trends in mortality and survival for specific cancers (end results).
CAREGEN: Genetic susceptibility and the risk of breast cancer This is an ancillary study of the NICHD Women’s CARE Study, a large population-based multi-center case-control study among Caucasian and African-American women that is designed primarily to evaluate the risk of breast cancer in women ages 35-64 in relation to oral contraceptive (OC) use and hormone replacement therapy (HRT).
EXCEL Study The ExCel research study is a breast cancer prevention clinical trial. It is an important international clinical trial designed to determine whether a special type of medication can prevent breast cancer in healthy postmenopausal women who are at an increased risk for developing breast cancer.
Markers of B-Cell Stimulation as Potential Predictors of Non-Hodgkin Lymphoma We are conducting a nested case-control study of biologic markers of a B-cell stimulatory host environment as predictors of B-cell NHL among 500 cases and 500 pair-matched controls from the WHI Observational Study (OS), among whom biologic samples were collected an average of 10 years before NHL diagnosis.
Molecular Change and Thyroid Cancer Risk After Chernobyl This study will investigate the occurrence and molecular characteristics of thyroid cancer in residents of the Bryansk Oblast of the Russian Federation who were up to 50 years of age at the time of exposure to radiation from the Chernobyl Power Station accident on April 26, 1986.
Molecular Epidemiology of Endometrial Cancer This study tests the hypotheses that the risk of developing endometrial cancer is related to variation in genes that encode for enzymes: 1) involved in the biosynthesis or catabolism of estrogens, or in the response to steroid hormones, and 2) that repair DNA damage generated during estrogen exposure.
Molecular Epidemiology of Lung Cancer A study determining whether polymorphisms of enzymes involved in the repair of smoking-induced DNA damage, namely those from the base excision (BER) and nucleotide excision repair (NER) pathways, are associated with risk of lung cancer.
Oral Cancer: Molecular Profiles & Clinical Outcomes Our goals in this study are to determine whether: 1) The prognosis of OSCC patients is associated with tumor gene expression profiles; 2) OSCC tumor characteristics known to be related to patient outcome - such as stage and nodal status - are associated with tumor gene expression profiles; and 3) Tumor gene expression differs among invasive OSCC, pre-neoplastic oral squamous cell lesions, and normal oral tissue.
Prostate Cancer Active Lifestyle Study (PALS) The PALS Study is enrolling for a study for prostate cancer patients who have chosen Active Surveillance of their cancer. The goal is to learn whether weight loss, through diet and exercise, will improve the health of men with low-grade prostate cancer.
Protein Biomarkers of Cancer Risk in Older Persons Using a case-cohort study design, this study evaluates if baseline plasma proteomic patterns can be used to distinguish between subjects who will and will not develop breast, colorectal, lung, and prostate cancers.
Quilt Study The Quilt Study is a study of predictors of disease progression and recurrence in women diagnosed with breast cancer at ages 45-79 to identify pre- and post-diagnosis exposures and events that may increase the risk of recurrence; assess pre-diagnosis exposures for their association with tumor characteristics and risk of recurrence; and
evaluate how tumor markers, both ones currently used in clinical care and novel ones not currently in use, relate to breast cancer progression or recurrence across age groups.
Study of Reflux Disease and Its Complications The Study of Reflux Disease and its Complications was conducted by scientists at the Fred Hutch between the years of 1998 and 2002. The data from this study are still in use by scientists in investigating the causes and complications of reflux disease.
Use of Exogenous Progestins and Risk of in situ and Invasive Breast Cancer The first project investigates the relationship between use of depo-medroxyprogesterone acetate on risk of in situ breast cancer among premenopausal women 20-44 years of age. The second study is a population-based case-control study evaluating the relationship between use of progestin containing hormone therapy regimens and risk of invasive pure lobular, ductal/lobular, and ductal carcinomas among postmenopausal women 55-74 years of age.
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