The Transdisciplinary Research on Energetics and Cancer (TREC) was a National Institutes of Health (NIH) initiative that supported eight Research Centers and one Coordination Center in two separate funding cycles, 2005-2010 and 2011-2016. The TREC Coordination Center, in partnership with the four Research Centers in each grant cycle, fostered collaboration among transdisciplinary teams of scientists with the goal of accelerating progress toward reducing cancer incidence, morbidity, and mortality associated with obesity, low levels of physical activity, and poor diet. The Centers also provided training opportunities for new and established scientists who could carry out integrative research on energy balance and cancer outcomes. The TREC initiative complemented NCI’s other energy balance research endeavors as well as efforts of the NIH Obesity Task Force. COMPASS served as the Coordination Center (CC), by supporting communication, dissemination, data sharing, and collaboration across the TREC initiative in both cycles, and continued until May 31, 2017.