Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation

Cancer Prevention Program

Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation

The objective of this nested case-control study is to elucidate mechanisms by which Vitamin D influences prostate cancer risk among 18,000 participants in the Prostate Cancer Prevention Trial (PCPT). Strong evidence from experimental studies indicates that vitamin D is involved in key carcinogenesis-related processes, including gene transcription, cellular differentiation, T-cell mediated immunity, cell cycle control, proliferation and apoptosis. We assayed baseline blood samples for serum concentrations of 25(OH)D and polymorphisms in a set of vitamin D related metabolizing genes. Prostate cancer outcomes were ascertained by biopsy in both cases and non-cases as part of the primary PCPT protocol.

Marian Neuhouser, PHD, RD

Marian Neuhouser, PHD, RD
Program Head, Cancer Prevention Program  

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Funding Agency:
National Cancer Institute  

Contact: 
Jeannette Schenk jschenk@fredhutch.org
Diana Lowry dlowry@fredhutch.org