Cancer Prevention Program

Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation

PI: Dr. Marian Neuhouser

This project is an ancillary study to the Prostate Cancer Prevention Trial. The objective of this project is to elucidate mechanisms by which Vitamin D influences prostate cancer risk. Strong evidence from experimental studies indicates that vitamin D is involved in key carcinogenesis-related processes, including gene transcription, cellular differentiation, T-cell mediated immunity, cell cycle control, proliferation and apoptosis. We will use serum measures of 25(OH)D, immunostain prostate biopsy tissue for the vitamin D receptor and assess genetic characteristics to meet the aims of the project.