Leadership & Faculty

Pathogen-Associated Malignancies Integrated Research Center

Leadership & Faculty

The Pathogen-Associated Malignancies Integrated Research Center (PAM IRC) brings together investigators with basic, translational, public health and clinical expertise who are committed to translation of basic findings from the laboratory to the clinic.

PAM IRC Leadership

Dr. Denise Galloway, PhD

Scientific Director
Dr. Denise Galloway oversees the PAM IRC’s vision and direction. She studies two cancer-causing viruses: The human papillomavirus, linked to all cervical cancers and a growing number of oropharyngeal and head and neck cancers, and Merkel cell polyomavirus, which causes 80 percent of Merkel cell carcinoma, a rare but aggressive skin cancer. Her work helped pave the way for the cancer-preventive HPV vaccine and led to a simple blood test to detect MCC recurrence.

Dr. Nina Salama, PhD

Co-director
Dr. Nina Salama works closely with Dr. Galloway to direct the PAM IRC. She leads mentoring and outreach efforts to junior faculty and other early-career scientists involved with the PAM IRC. Dr. Salama studies Helicobacter pylori, a common bacterial pathogen linked to stomach ulcers, a majority of gastric cancer cases and certain lymphomas.

Dr. Hootie Warren, MD, PhD

As head of the Fred Hutch Global Oncology Program, Dr. Hootie Warren links PAM IRC research interests with ongoing work in areas of the world most impacted by pathogen-associated malignancies. He balances clinical care of patients with blood cancers with cancer immunology research. A major focus of his research is Burkitt lymphoma, a common B-cell cancer in sub-Saharan Africa that is caused by the Epstein–Barr virus.

Dr. Paul Nghiem, MD, PhD

Dr. Paul Nghiem brings clinical and translational expertise to the PAM IRC. He is a world expert in the study and treatment of Merkel cell carcinoma, an aggressive, rare skin cancer that is linked to Merkel cell polyomavirus in 80 percent of cases.


PAM IRC Faculty

Alphabetical Listing:

Select a letter to display a list of Faculty members
A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z  [Show All]
Assistant Member, Human Biology Division
Affiliate Member, Basic Sciences Division
Affiliate Assistant Professor, Department of Microbiology, University of Washington
The mechanisms by which viruses hijack chromatin. Due to the major advancement in sequencing technologies and the expansion of the field of epigenetics, exploiting viruses to investigate chromatin biology has enormous potential.
Phone: (206) 667-2755
Characterizes virus diversity, evolution, circulation patterns. Identifies epidemiological patterns from sequence data and develops methods to predict evolutionary growth or decay across strains.
Phone: (206) 667-6372
Associate Member, Basic Sciences Division
Howard Hughes Medical Institute Investigator, Howard Hughes Medical Institute
Molecular evolution of viruses and proteins
Phone: (206) 667-3622
Fax: (206) 667-6525
Head, Infectious Disease Sciences Program, Vaccine and Infectious Disease Division
Professor, Medicine, University of Washington
Attending Physician and Head, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
Infections in the immunocompromised host, especially diagnosis, prevention and treatment of CMV, VZV, BK virus, adenovirus, and respiratory virus infections. Research includes understanding the genetic basis of infection complications, genome and gene expression studies.
Phone: (206) 667-6706
Fax: (206) 667-4411
Assistant Member, Clinical Research Division
Assistant Professor, Department of Medicine, Division of Medical Oncology, University of Washington
Attending Physician, Seattle Cancer Care Alliance
Research is centered on 1) understanding the factors associated with successful adoptive transfer of immune T cells and improving the outcomes of both native and gene-modified T cells targeting viral and tumor antigens, 2) developing methods that improve the survival, proliferation and anti-tumor activity of infused T-cell products so as to better eliminate tumor targets and 3) clinical strategies to modulate the host immune environment as a means to optimally activate T cells in humans.
Phone: (206) 667-4369
Fax: (206) 667-7983

Lab @ Fred Hutch

Chapuis Lab

Professor of Medicine/Oncology, University of Washington
Immunotherapy cancer vaccines and solid tumor research
Phone: (206) 667-4141
Fax: (206) 667-6366
Full Member, Epidemiology, Public Health Sciences Division
Affiliate Professor, Otolaryngology: Head and Neck Surgery, University of Washington School of Medicine
Affiliate Professor, Epidemiology, University of Washington School of Public Health
Graduate School Faculty, Epidemiology, University of Washington School of Public Health
Etiology of tobacco-related cancers (head and neck cancer, lung cancer); etiology of hormone-related cancers (breast, endometrium, prostate, testes); prognostic gene signatures for oral cancer.
Phone: (206) 667-6644
Fax: (206) 667-2537
President and Director Emeritus, Fred Hutchinson Cancer Research Center
Professor, Medicine and Laboratory Medicine, University of Washington
Research focus is HIV and herpesvirus vaccine development, herpes simplex virus type 2 (HSV-2) pathogenesis and the host immune response. Immunotherapeutic approaches to viral infections and cancer
Phone: (206) 667-6770
Fax: (206) 667-7711
Assistant Member, Clinical Research Division
Gastroenterologist, Seattle Cancer Care Alliance
Research focus: gut microbiome, metagenomics, bile acid metabolism, motility, gastrointestinal cancers. Clinical focus: inflammatory bowel disease, gastrointestinal cancers.
Phone: (206) 667-6649
Editor-in-Chief (as of Jan. 1, 2013), Virology
Associate Editor, PLoS Pathogens
HIV replication and virus interaction with host cells
Phone: (206) 667-5058
Fax: (206) 667-6523
Professor, Medicine, University of Washington
Adjunct Associate Professor, Microbiology, University of Washington
Director, Infectious Diseases Fellowship Training Program, University of Washington
Determining how changes in microbial communities impact human health; identifying, characterizing, and culturing microbes found in the human genital tract; and associating the reproductive tract microbiome with human disease. Developing molecular diagnostic tests to detect and identify pathogens in immunocompromised hosts such as cancer patients.
Phone: (206) 667-1935
Fax: (206) 667-4411
Paul Stephanus Memorial Endowed Chair, Fred Hutchinson Cancer Research Center
The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.
Phone: (206) 667-4500
Fax: (206) 667-5815
Attending Physician, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses
Phone: (206) 667-5122
Fax: (206) 667-6523
Scientific Director, Translational Data Science Integrated Research Center, Fred Hutchinson Cancer Research Center
J. Orin Edson Foundation Endowed Chair, Fred Hutchinson Cancer Research Center
Affiliate Professor, Statistics, University of Washington
Developing methods and tools for high-throughput, high-dimensional experiments with applications in vaccine research, immunology and immunotherapy; flow cytometry, peptide microarrays, next generation sequencing; Bayesian inference and computation and statistical computing
Phone: (206) 667-4076
Fax: (206) 667-4378
Rodger C. Haggitt Professor, Division of Gastroenterology, University of Washington School of Medicine
Medical Director, GI Cancer Prevention Program Clinic, Seattle Cancer Care Alliance
Molecular and cell biology of gastrointestinal cancer; genetic and epigenetic alterations in cancer.
Phone: (206) 667-1107
Fax: (206) 667-2917
Member & Head, Program in Immunology, Clinical Research Division
Professor of Medicine & Immunotherapy, University of Washington
Basic immunology and cancer immunobiology, and on the development and assessment of adoptive therapies with antigen-specific T cells targeting human malignancies and chronic infections.
Phone: (206) 667-7791
Fax: (206) 667-7983
Professor, Laboratory Medicine, University of Washington
Head, Virology Division, University of Washington
Director, Molecular Virology Laboratory, Laboratory Medicine, University of Washington
Clinically important persistent and latent viral infections; curative therapies for latent viral infections ;diagnosis of disease caused by herpesviruses, enterovirus, JC and BK viruses, parvovirus B19, and hepatitis viruses
Phone: (206) 667-6793
Fax: (206) 667-6179
Stephanus Family Endowed Chair for Cell and Gene Therapy, Clinical Research Division
Director, Stem Cell and Gene Therapy Program, Clinical Research Division
Associate Head of Transplantation Biology, Clinical Research Division
The Kiem Lab is focused on research and clinical trials using stem cell biology and stem cell gene transfer with the goal of developing stem cell-based treatment strategies for patients with genetic or infectious stem cells. We are conducting studies using embryonic stem cells and induced pluripotent stem cells.
Phone: (206) 667-4409
Fax: (206) 667-6124
Assistant Member, Basic Sciences Division
Understanding how maternal-fetal interactions regulate neonatal health
Phone: (206) 667-3655
Member and Associate Director, Public Health Sciences Division
Cancer Prevention Program, Public Health Sciences Division
Controlled dietary studies, nutrition interventions and phytochemicals.
Phone: (206) 667-6580
Fax: (206) 667-7850
Associate Member, Program in Epidemiology, Public Health Sciences Division
Research Associate Professor, Department of Epidemiology, University of Washington, School of Public Health and Community Medicine
Cancer epidemiology; epidemiology of HPV-related cancer; immunoepidemiology; immunogenetics of cancer
Phone: (206) 667-4630
Fax: (206) 667-5948
Member and Associate Director, Basic Sciences Division
Howard Hughes Medical Institute Investigator, Howard Hughes Medical Institute
Evolutionary and functional studies of genetic conflict
Phone: (206) 667-5204
Fax: (206) 667-6497
Associate Medical Director, Adult Solid Tumor Oncology, Seattle Cancer Care Alliance
Clinical Research Director, Thoracic and Head and Neck Oncology, Seattle Cancer Care Alliance
Full Member, Clinical Research Division, Fred Hutchinson Cancer Research Center
Professor of Medicine, University of Washington
Stephen H. Petersdorf Endowed Chair in Cancer Care, University of Washington
Research is focused immunotherapy, targeted therapies and the design of clinical trials for head and neck and lung cancers
Phone: (206) 606-6723
Fax: (206) 606-1435
Phone: (206) 667-7318
Fax: (206) 667-1319
Senior Vice President and Director, Vaccine and Infectious Disease Division
Professor of Medicine, University of Washington
Adjunct Professor, Pathobiology, Global Health, and Laboratory Medicine, University of Washington
Research centers on developing an HIV vaccine and investigating the complex relationship between HIV and the immune system and the influence of antiretroviral therapy.
Assistant Member, Immunology and Vaccine Development, Vaccine and Infectious Disease Division
Research interests include HIV-1 immunogen design, the development of broadly neutralizing antibodies for HIV-1 infection and antigen-B cell interactions.
Assistant Member, Clinical Research Division
Assistant Professor, Department of Medicine, University of Washington School of Medicine
Current research is to enhance cancer diagnostics in Uganda and in improving the care of patients with cancer in resource-limited regions.
Phone: (206) 667-4636
Fax: (206) 667-1965
Research focuses on development and application of novel methods for identifying and characterizing antigen specific T cells in the context of cancer and chronic infection with the goal of identifying specific and accurate biomarkers of human health and disease based on antigen-specific T cells.
Phone: (206)667-2807
Fax: (206) 667-7711
Affiliate Investigator, Clinical Research Division
Director, Skin Oncology Clinical Program, Seattle Cancer Care Alliance
George F. Odland Endowed Chair in Dermatology, University of Washington
Head of Dermatology, University of Washington
Professor of Dermatology/Medicine and Adjunct Professor of Oral Health Sciences and Pathology, University of Washington
New ways to prevent and treat skin cancers by studying the systems that control cell division. These systems help prevent cells with damaged DNA from reproducing and, when they malfunction, can affect cells’ chances of becoming cancerous.
Phone: (206) 221-2632
Fax: (206) 221-4364
Endowed Chair for Graduate Education, Fred Hutchinson Cancer Research Center
The Overbaugh lab has a long-standing interest in understanding the mechanisms of HIV-1 transmission and pathogenesis. The lab is part of a larger team, comprising researchers in both Seattle and Kenya (The Nairobi HIV/STD Project). Trainees in the lab have opportunities to engage in studies of viral evolution, virus-host cell interactions, and viral immunology all within the context of international collaboration.
Phone: (206) 667-3524
Fax: (206) 667-6524
Medical Director, UCI-Fred Hutch Collaboration, UCI / Hutchinson Center Cancer Alliance
Attending Physician, Infectious Disease Consulting Service , Patient Care and Clinical Services
Viral, immunologic, and host genetic factors associated with Kaposi sarcoma presentation and survival outcomes.
Phone: (206) 667-4600
Fax: (206) 667-1965
Member, Program in Immunology, Clinical Research Division
Scientific Director, Immunopathology Lab, Clinical Research Division
Mechanisms of tumor-induced immune tolerance by which tumors can escape anti-tumor immune responses, including natural and therapy-induced responses
Phone: (206) 667-6648
Fax: (206) 667-7983
Affiliate Associate Professor, Department of Global Health, University of Washington
Faculty Member, Interdisciplinary Program in Pathobiology, University of Washington
Faculty Member, Molecular & Cellular Biology Program, Fred Hutch & University of Washington
Study T cell fate and function in healthy and inflamed tissues and following infection with HIV and manipulate these responses for therapeutic purposes
Phone: (206) 667-2216
Fax: (206) 667-2209
Member, Cancer Prevention Program, Public Health Sciences Division
Comparative effectiveness analysis; cost effectiveness analysis, health economics, cancer outcomes research.
Phone: (206) 667-7846
Fax: (206) 667-5977
Member, Clinical Research Division, Program in Immunology, Program in Immunology
Professor, School of Medicine, University of Washington
Attending Physician, Seattle Cancer Care Alliance
Studies focus on 1) understanding the roles of distinct T cell subsets in protective immunity to pathogens and tumors and on 2) the development and clinical application of adoptive T cell therapies for viral diseases and cancers, using unmodified and genetically modified antigen-specific T cells.
Phone: (206) 667-7791
Fax: (206) 667-7983
Affiliate Member, Basic Sciences Division
Dr. Penny E. Petersen Memorial Chair for Lymphoma Research, Fred Hutchinson Cancer Research Center
Director of Molecular and Cellular Biology (MCB) Graduate Program, Fred Hutchinson Cancer Research Center
The Salama lab studies the gastric bacterial pathogen Helicobacter pylori, which infects half the world's population and can cause ulcers and gastric cancer.
Phone: (206) 667-1540
Fax: (206) 667-6524
Associate Member, Clinical Research Division
Associate Professor, Department of Medicine, University of Washington
Attending Physician, SCCA Infectious Consulting Service, Seattle Cancer Care Alliance
Interest in describing the quantitative and dynamical features of human pathogens and immune responses. Most of work to-date is on the pathogenesis of HSV-2 infection but also interested in applying models to optimize viral eradication strategies, and to use models to capture kinetic features of the human microbiome.
Professor of Epidemiology, University of Washington
Genetic, lifestyle, and environmental determinants of neoplasia and its sequelae.
Phone: (206) 667-4660
Fax: (206) 667-5948
Affiliate Professor, Department of Global Health, University of Washington
Research is focused on the development of a safe and effective vaccine to combat the spread of HIV and to investigate how HIV infection leads to AIDS. Two major areas of research is to better understand how neutralizing antibodies against HIV are developed during natural HIV-infection,and engineer immunogens that will elicit broadly neutralizing antibody responses against HIV.
Phone: (206) 667-2995
Fax: (206) 667-7767
Structural molecular immunology and vaccinology: using biophysical approaches to study proteins and interactions mediating or modulating adaptive and innate immune responses
Phone: (206) 667-5587
Fax: (206) 667-5939
Assistant Member, Immunology and Vaccine Development, Vaccine and Infectious Disease Division
Affiliate Assistant Professor, Department of Global Health, University of Washington
Affiliate Assistant Professor, Department of Immunology, University of Washington
Faculty Member, Molecular & Cellular Biology Program, University of Washington
Research interests involve mechanisms driving the differentiation of B cells following vaccination and infection, understanding how differences in the pre-immune repertoire influences immunity and vaccine Development
Member, Cancer Prevention Program, Public Health Sciences Division
Associate Director for Minority Health and Health Disparities Emeritus, Fred Hutch, Health Disparities Research Center
Cancer and health disparities; Community approaches to smoking cessation, dietary change and screening behaviors for cancer prevention.
Phone: (206) 667-4673
Fax: (206) 667-5977
Deputy Head, Global Oncology
Associate Member, Clinical Research Division
Associate Professor of Medicine, University of Washington School of Medicine
Major research interests are the pathogenesis and management of viral-associated malignancies, including cancers that occur in the setting of HIV.
Phone: (206) 667-7585
Fax: (206) 667-1965
Professor, Medicine, Laboratory Medicine, and Epidemiology, University of Washington
Graduate Faculty, Medicine, Laboratory Medicine, and Epidemiology, University of Washington
Head, Division of Allergy & Infectious Diseases, University of Washington
Attending Physician, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
Epidemiology, natural history, therapy, and prevention of HSV and other herpesvirus infections; interactions between HSV and HIV Vaccines and clinical trials
Phone: (206) 520-4340
Member, Program in Immunology, Clinical Research Division
Professor of Medicine, Department of Medicine, University of Washington
Attending Physician, Seattle Cancer Care Alliance
Program Head, Global Oncology, Global Oncology
Clinical focus is treating patients with blood cancers such as leukemia, lymphoma, and multiple myeloma. Research is focused on cancer immunology, specifically the mechanisms and molecules that mediate graft-versus-host disease and graft-versus tumor.
Phone: (206) 667-6441
Fax: (206) 667-7983

Members from the Fred Hutch / University of Washington Cancer Consortium and other institutions

Brittany Barber, Assistant Professor, University of Washington

Ruanne Barnabas, Assistant Professor, University of Washington

Corey Casper, Member, Infectious Disease Research Institute

Michael Chung, Associate Professor, University of Washington

Willam DePaolo, Associate Professor, University of Washington

Tina Fitzmaurice, Assistant Professor, University of Washington

Lisa Frenkel, Professor, Seattle Children's Hospital

Michael Gale, Professor, University of Washington

Soren Gantt, Associate Professor, BC Children's Hospital

Susan Graham, Associate Professor, University of Washington

Steve Hawes, Associate Professor, University of Washington

Florian Hladik, Professor, University of Washington

David Koelle, Professor, University of Washington

Michael Lagunoff, Professor, University of Washington

Jaisri Lingappa, Professor, University of Washington

Nelly Mugo, Associate Professor, University of Washington

Steve Polyak, Professor, University of Washington

Christina Rodriguez, Associate Professor, University of Washington

Tim Rose, Professor, University of Washington

Ram Savan, Associate, University of Washington

John Scott, Associate Professor, University of Washington

Jason Smith, Associate Professor, University of Washington

Dan Stetson, Associate Professor, University of Washington

Vivien Tsu, Professor, PATH

Judy Wasserheit, Professor, University of Washington

Rachel Winer, Associate Professor, University of Washington

Long Fu Xi, Associate Professor, University of Washington

Matthew Yeh, Professor, University of Washington