Beronja Lab Human Biology Regulation of epithelial growth in development and cancer. Tissue growth is a fundamental biological process that generates functional organs in development, and maintains them in the adulthood through continuous cycles of renewal and repair.
Bielas Lab Public Health Sciences, Human Biology The Bielas Lab studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the development of cancer and age-related disease. Translational research projects explore the potential utility of these mutations as novel DNA biomarkers for improved disease detection, treatment outcome, survival and quality of life.
Bolouri Lab Human Biology The Bolouri Lab is interested in understanding how gene regulatory interactions control cellular state and identity, particularly during development (e.g. in stem cells). The lab specializes in the development and use of computational systems biology methods to map gene regulatory networks.
Emerman Lab Human Biology, Basic Sciences The Emerman Lab studies the molecular and evolutionary basis for the replication of HIV and related viruses, with an emphasis on the interaction of these viruses with their host cells. Their goal is to understand what determines resistance or vulnerability to current, past and potential viral diseases.
Galloway Lab Public Health Sciences, Human Biology The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.
Geballe Lab Clinical Research, Human Biology The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses.
Grandori Lab Human Biology The Grandori Lab focuses on exploiting the weaknesses of cancer cells to identify targeted, less toxic cancer therapies. RNA interference (RNAi) combined with high throughput technology enables us to interrogate the human genome for genes that are essential for viability of molecularly defined cancer cells, thus allowing the unbiased identification of these Achilles' heels.
Hockenbery Lab Clinical Research, Human Biology The Hockenbery lab studies programmed cell death (apoptosis) pathways that are defective in many cancer cells; and the role of cancer-cell metabolism in apoptosis, oncogene functions, and environmental/dietary risk factors, including excess supply of nutrients. After identifying cancer-selective targets, they carry out small-molecule screens for inhibitors to identify lead compounds as anticancer agents.
Holland Lab Human Biology The Holland lab works at the intersection of multiple disciplines to address the molecular basis of brain tumors and develop new approaches to their treatment. Our research focuses on developing mouse models of brain cancer that mimic the behavior of the disease in patients. Our work with mouse models has led to clinical trials in glioma patients. We also have developed imaging strategies to follow mouse brain tumors as they develop—a powerful system that is used to test promising new drugs with potential benefit for patients.
Hsieh Lab Human Biology The primary focus of the Hsieh lab is to unravel the post-transcriptional mechanisms that govern the genesis and progression of epithelial malignancies. Our research seeks to understand how rogue cells co-opt the critical interface between RNA and the protein synthesis machinery to drive specific cancer behavior at a molecular, cellular, and organismal level.
Kemp Lab Public Health Sciences, Human Biology The Kemp Lab studies tumor formation in mice to better understand how environmental and genetic factors interact to cause cancer. They also work to develop simple blood tests for early cancer detection by discovering biomarkers, the proteins that signal the earliest traces of disease.
Laboratory for the Study of Metastatic Microenvironments Human Biology Dr. Ghajar directs the Laboratory for the Study of Metastatic Microenvironments (LSM2). The goal of his research program is to understand how microenvironments within distant tissues regulate dormancy and growth of disseminated tumor cells (DTCs), and whether these niches convey chemoresistance to dormant DTCs. His belief is that solving these puzzles will allow the development of therapeutic regimens that eradicate dormant DTCs before they can develop into full-blown metastases.
Lampe, P Lab Public Health Sciences, Human Biology The Paul Lampe Lab attempts to discover early detection cancer biomarkers and investigates the control of cell growth at the cell biology level. Of particular interest is the role that gap junctions play in the regulation of cell growth and the cell cycle, and the disruption of this relationship during cancer development.
MacPherson Lab Public Health Sciences, Human Biology The MacPherson Lab is focused on understanding the mechanisms through which cancer-mutated genes drive tumorigenesis. The lab studies two tumor types, small cell lung carcinoma (SCLC) and retinoblastoma. Genomic analyses of human tumors allow us to identify gene mutations that may contribute to tumor initiation, progression and metastasis.
Neiman Lab Basic Sciences, Human Biology Cellular and viral oncogenes; normal and neoplastic B-cell development in the bursa of Fabricius; functional genomic analysis of somatic genomic instability in cancer
Overbaugh Lab Public Health Sciences, Human Biology The Overbaugh lab has a long-standing interest in understanding the mechanisms of HIV-1 transmission and pathogenesis. The lab is part of a larger team, comprising researchers in both Seattle and Kenya (The Nairobi HIV/STD Project). Trainees in the lab have opportunities to engage in studies of viral evolution, virus-host cell interactions, and viral immunology all within the context of international collaboration.
Paddison Lab Public Health Sciences, Human Biology The Paddison Lab uses functional genetics to probe the underlying biology of mammalian stem/progenitor cells. We identify and characterize gene products affecting stem cell self-renewal, differentiation, proliferation, or survival through the use of RNAi knockdown technologies.
Peichel Lab Human Biology, Basic Sciences The Peichel Lab uses a small fish called the threespine stickleback as a model organism to conduct research aimed at identifying the genetic and molecular mechanisms that underlie evolutionary processes. Research topics include understanding evolution of the fish's behavior and sex chromosomes.
Peter Nelson Lab Human Biology Dr. Peter Nelson's lab focuses on understanding the molecular, cellular and physiological events that lead to cancer initiation and progression. A particular emphasis involves hormonal carcinogenesis and prostate cancer with the goal of developing new strategies for diagnosis, prognosis and therapy.
Porter Lab Public Health Sciences, Human Biology The Porter Lab focuses on identifying and understanding the molecular events in normal and cancer cells that are associated with the initiation and progression of human cancer, with a focus on breast and ano-genital cancers. They also investigate the molecular profiles that distinguish different types of cancer or determine an individual's cancer risk.
Reid Lab Public Health Sciences, Human Biology The Reid Lab is focused on understanding the mechanisms by which environmental exposures (i.e. aspirin or other nonsteroidal antiinflammatory agents) affect the evolution of clones that lead to the development of esophageal adenocarcinoma in patients with Barrett's esophagus.
Salama Lab Public Health Sciences, Human Biology The Salama lab studies the gastric bacterial pathogen Helicobacter pylori, which infects half the world's population and can cause ulcers and gastric cancer.
Simon Lab Clinical Research, Human Biology The overarching goal of the projects in the Simon laboratory is the development of small molecules as mechanistic probes for a variety of cellular processes and as potential lead compounds for the development of therapeutic agents. To this end we apply an interdisciplinary approach ranging from chemical synthesis and medicinal chemistry to genetics and cell biology. The compounds we are studying have been identified from large collections of synthetic, drug-like compounds and from natural sources. While screening compound libraries is a significant part of what we do the majority of our efforts go into mechanistic studies to understand the biology and pharmacology of lead compounds and efforts to improve their activity through chemical synthesis of analogs.
Taniguchi Lab Public Health Sciences, Human Biology The Taniguchi Lab's long-term research objective is to elucidate molecular mechanism of DNA damage response pathways, such as the Fanconi Anemia-BRCA (FA-BRCA) pathway, and their involvement in carcinogenesis.
Tapscott Lab Clinical Research, Human Biology The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.
Transmission of Stomach Bacteria Study Human Biology Fred Hutchinson Cancer Research Center is recruiting families to participate in a study about the transmission of Helicobacter pylori, a stomach bacteria infecting half of the world's population. The bacteria can cause ulcers and stomach cancer.
Vasioukhin Lab Human Biology The Vasioukhin lab studies the mechanisms and significance of cell polarity and cell adhesion in normal mammalian development and cancer. In addition, we have a significant interest in the mechanisms responsible for initiation and progression of human prostate cancer. We believe that it is important to study cells in their normal microenvironment.