Faculty & Labs

Human Biology Division

Faculty & Labs

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Assistant Member, Human Biology Division
Affiliate Member, Basic Sciences Division
Affiliate Assistant Professor, Department of Microbiology, University of Washington
The mechanisms by which viruses hijack chromatin. Due to the major advancement in sequencing technologies and the expansion of the field of epigenetics, exploiting viruses to investigate chromatin biology has enormous potential.
Phone: (206) 667-2755
Assistant Member, Human Biology Division
The goal of the Berger laboratory is to enable precision medicine by systematically uncovering the molecular alterations in cancer, determining the function of these variant alleles, and understanding how these alleles modulate response to targeted or immune-based therapies.
Phone: (206) 667-6281
Assistant Member, Human Biology Division
The Beronja Lab studies molecular and cellular mechanisms that are essential for tissue growth during development and tumorigenesis. Our goal is to identify genes and gene pathways that can be used as targets in cancer therapy with a particular focus on the regulators of the balance between stem cell renewal and differentiation.
Phone: (206) 667-7609
Fax: (206) 667-2917
The Bielas Laboratory studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the pathogenesis of cancer and age-related disease.
Phone: (206) 667-3170
Fax: (206) 667-2537
Affiliate Investigator, Human Biology Division
Interested in understanding how gene regulatory interactions control cellular state and identity, both in normal development (e.g. in stem cell differentiation) and in diseases such as cancer. A particular focus is the development and use of integrative computational systems biology methods to map gene regulatory networks from whole genome data (sequence, expression, DNA methylation, miRNA-seq, etc).
Assistant Member, Translational Research Program, Public Health Sciences Division
Assistant Member, Human Biology Division
The Cheung lab studies the cellular and molecular biology of tumor cell clusters and their role in breast cancer metastasis.
Phone: (206) 667-6276
Executive Vice President and Deputy Director, Fred Hutchinson Cancer Research Center
Professor, Department of Medicine, University of Washington
Rosput Reynolds Endowed Chair, Fred Hutchinson Cancer Research Center
The Clurman Lab studies how cell division is regulated in normal cells, and how abnormal control of cell division leads to cancer. They hope to use these mechanistic insights into tumor formation to develop new cancer treatment strategies.
Phone: (206) 667-4524
Fax: (206) 667-5255
Affiliate Investigator, Human Biology Division
Genomic duplication followed by adaptive mutation is considered one of the primary forces for evolution of new function. Duplicated sequences are also dynamic regions of rapid structural change during the course of chromosome evolution. The long-term goal of his research is to understand the evolution, pathology and mechanism(s) of recent gene duplication and DNA transposition within the human genome. His work involves the systematic discovery of these regions, the development of methods to assess their variation, the detection of signatures of rapid gene evolution and ultimately the correlation of this genetic variation with phenotypic differences within and between species.
Phone: (206) 543-9526
Fax: (206) 543-6575
Editor-in-Chief (as of Jan. 1, 2013), Virology
Associate Editor, PLoS Pathogens
HIV replication and virus interaction with host cells
Phone: (206) 667-5058
Fax: (206) 667-6523
Paul Stephanus Memorial Endowed Chair, Fred Hutchinson Cancer Research Center
The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.
Phone: (206) 667-4500
Fax: (206) 667-5815
Attending Physician, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses
Phone: (206) 667-5122
Fax: (206) 667-6523
Assistant Member, Human Biology Division
Dr. Ghajar directs the Laboratory for the Study of Metastatic Microenvironments (LSM2). The goal of his research program is to understand how microenvironments within distant tissues regulate dormancy and growth of disseminated tumor cells (DTCs), and whether these niches convey chemoresistance to dormant DTCs. His belief is that solving these puzzles will allow the development of therapeutic regimens that eradicate dormant DTCs before they can develop into full-blown metastases.
Phone: (206) 667-7080
Fax: (206) 667-2537
Assistant Member, Human Biology Division
Affiliate Assistant Professor, University of Washington (Pharmacology)
Understanding how networks of signaling proteins are wired in different cell types and how they influence response to growth factors or cytotoxic agents using both hypothesis driven and systems-based data-driven approaches.
Phone: (206) 667-4149
Assistant Member, Basic Sciences Division
Assistant Member, Human Biology Division
Mammalian nuclear envelope remodeling in interphase
Phone: (206) 667-5116
Fax: (206) 667-6522
The Hockenbery lab studies programmed cell death (apoptosis) pathways that are defective in many cancer cells; and the role of cancer-cell metabolism in apoptosis, oncogene functions, and environmental/dietary risk factors, including excess supply of nutrients. After identifying cancer-selective targets, they carry out small-molecule screens for inhibitors to identify lead compounds as anticancer agents.
Phone: (206) 667-4611
Fax: (206) 667-6519
Senior VP and Director , Human Biology Division
Director, Seattle Translational Tumor Research, Fred Hutchinson Cancer Research Center and UW Medicine
Chap and Eve Alvord and Elias Alvord Chair in Neuro-Oncology, UW Medicine
Professor of Neurological Surgery, University of Washington
Research focus is the molecular basis of brain tumors and the development of new targeted treatment approaches. Mouse models of brain cancer that mimic disease behavior in patients have been developed which have led to clinical trials in glioma patients.
Phone: (206) 667-6117
Fax: (206) 667-7850
Associate Professor, Division of Pulmonary and Critical Care Medicine, University of Washington
The Houghton Lab studies the immune cell composition and function in solid tumor malignancies, most prominently in non-small cell lung cancer (NSCLC). The group has established a platform to combine the study of human tissue specimens and mouse models of cancer to address key questions ranging from mechanisms of immune escape and treatment failures to the identification of novel biomarkers for lung cancer early detection. This platform has revealed an essential role for myeloid lineage cells—particularly neutrophils—in excluding tumor-reactive lymphocytes from the malignant portion of tumors. The current focus of the lab is to determine the mechanistic basis of lymphocyte-excluded NSCLCs and to develop therapeutic strategies to circumvent their exclusion.
Phone: (206) 667-3175
Fax: (206) 667-5255
Assistant Member, Human Biology Division
Assistant Member, Clinical Research Division
Assistant Professor, Department of Medicine, University of Washington
The goal of the Hsieh lab is to understand how deregulation of protein synthesis control determines the fate of epithelial cells in the multi-step process of tumor initiation and progression. Our long term goal is to merge our fundamental discoveries in translational control biology with the clinical needs of cancer patients.
Phone: (206) 667-7356
Fax: (206) 667-6523
The Kemp Lab seeks to identify the next generation of targeted anticancer agents. We use a combination of high throughput functional genomic and small molecule screens, and genomic analysis applied to a range of isogenic and patient derived tumor models. We are discovering and validating novel drug targets and therapeutic options for multiple solid tumor types including pancreatic, ovarian, head and neck and breast cancer.
Phone: (206) 667-4252
Fax: (206) 667-5815
Assistant Member, Human Biology Division
The central theme of the Kugel Lab is to study how the dysregulation of chromatin modifying enzymes contributes to pancreatic cancer pathogenesis and, further, whether these pathways present liabilities that could be exploited for cancer therapy.
Phone: (206) 667-3648
Intercellular communication and the control of cell growth.
Phone: (206) 667-5408
Fax: (206) 667-2537
Assistant Member, Human Biology Division
The primary goal of the research is to identify vulnerabilities for therapeutic exploitation to enhance and extend life for patients with late-stage prostate cancer.
Phone: (206) 667-6819
Fax: (206) 667-4023
Associate Member, Human Biology Division
The MacPherson Lab is focused on understanding the mechanisms through which cancer-mutated genes drive tumorigenesis. The lab studies small cell lung cancer and other solid tumors. We generate novel genetically engineered mouse models that we use to interrogate the biology underlying major cancer driver genes. We are particularly interested in understanding epigenetic regulators that are genetically mutated in human tumors.
Phone: (206) 667-6464
Fax: (206) 667-2917
Member Emeritus, Basic Sciences Division
Member Emeritus, Human Biology Division
Cellular and viral oncogenes; normal and neoplastic B-cell development in the bursa of Fabricius; functional genomic analysis of somatic genomic instability in cancer
Phone: (206) 667-4417
Fax: (206) 667-6523
Endowed Chair for Prostate Cancer Research, Fred Hutchinson Cancer Research Center
Research focus is the understanding the molecular, cellular and physiological events that lead to cancer initiation and progression. A particular emphasis involves hormonal carcinogenesis and prostate cancer with the goal of developing new strategies for diagnosis, prognosis and therapy.
Phone: (206) 667-3377
Fax: (206) 667-2917
Endowed Chair for Graduate Education, Fred Hutchinson Cancer Research Center
The Overbaugh lab has a long-standing interest in understanding the mechanisms of HIV-1 transmission and pathogenesis. The lab is part of a larger team, comprising researchers in both Seattle and Kenya (The Nairobi HIV/STD Project). Trainees in the lab have opportunities to engage in studies of viral evolution, virus-host cell interactions, and viral immunology all within the context of international collaboration.
Phone: (206) 667-3524
Fax: (206) 667-6524
Associate Member, Human Biology Division
The Paddison Lab uses functional genomics to probe the underlying biology of normal and cancerous stem/progenitor cells. We identify and characterize gene products affecting stem cell self-renewal, differentiation, proliferation, or survival through the use of CRISPR-Cas9 and RNAi technologies. For our cancer studies we create novel models of precision functional genomics directly in patient tumor isolates.
Phone: (206) 667-4312
Fax: (206) 667-4023
The Porter Lab focuses on identifying and understanding the molecular events in normal and cancer cells that are associated with the initiation and progression of human cancer, with a focus on breast and ano-genital cancers. They also investigate the molecular profiles that distinguish different types of cancer or determine an individual's cancer risk.
Phone: (206) 667-3751
Fax: (206) 667-5815
The Reid Lab is focused on understanding the mechanisms by which environmental exposures (i.e. aspirin or other nonsteroidal antiinflammatory agents) affect the evolution of clones that lead to the development of esophageal adenocarcinoma in patients with Barrett's esophagus.
Fax: (206) 667-6192
Assistant Member, Human Biology Division
Assistant Member, Clinical Research Division
Development of unique model systems for the study of a form of liver cancer called cholangiocarcinoma, or biliary tract cancer, to understand the fundamental pathogenic mechanisms of liver carcinogenesis and to identify new targeted therapies for specific genetic subsets of this disease.
Affiliate Member, Basic Sciences Division
Dr. Penny E. Petersen Memorial Chair for Lymphoma Research, Fred Hutchinson Cancer Research Center
Director of Molecular and Cellular Biology (MCB) Graduate Program, Fred Hutchinson Cancer Research Center
The Salama lab studies the gastric bacterial pathogen Helicobacter pylori, which infects half the world's population and can cause ulcers and gastric cancer.
Phone: (206) 667-1540
Fax: (206) 667-6524
Associate Professor, University of Washington
Affiliate Investigator, Human Biology Division
The mission of the Shendure Lab is to develop and apply new technologies in genomics and molecular biology. Most projects in the lab exploit new DNA sequencing technologies, and generally fall into one of six areas: 1) next-generation human genetics; 2) genome contiguity & completeness; 3) massively parallel functional analysis; 4) molecular tagging; 5) synthetic biology; 6) translational genomics.
Phone: (206) 685-8543
Fax: (206) 685-7301
Associate Member, Clinical Research Division
Associate Member, Human Biology Division
The overarching goal of the projects in the Simon laboratory is the development of small molecules as mechanistic probes for a variety of cellular processes and as potential lead compounds for the development of therapeutic agents. To this end we apply an interdisciplinary approach ranging from chemical synthesis and medicinal chemistry to genetics and cell biology. The compounds we are studying have been identified from large collections of synthetic, drug-like compounds and from natural sources. While screening compound libraries is a significant part of what we do the majority of our efforts go into mechanistic studies to understand the biology and pharmacology of lead compounds and efforts to improve their activity through chemical synthesis of analogs.
Phone: (206) 667-6241
Fax: (206) 667-5669
Assistant Member, Human Biology Division
Broadly seeks to understand how metabolism is used to support cell function. A major focus is to identify the metabolic pathways that are particularly required for cancer growth and progression, with the goal to identify new targets for cancer therapy.
Phone: (206) 667-7826
The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.
Phone: (206) 667-4499
Fax: (206) 667-6524
Member and Director Emeritus, Human Biology Division
The Vasioukhin lab studies the mechanisms and significance of cell polarity and cell adhesion in normal mammalian development and cancer. In addition, we have a significant interest in the mechanisms responsible for initiation and progression of human prostate cancer. We believe that it is important to study cells in their normal microenvironment.
Phone: (206) 667-1710
Fax: (206) 667-6524