Clinical Research Division Labs & Projects
- Bedalov Lab
The Bedalov Lab conducts research to identify drugs that disrupt gene silencing, a process that has been implicated in cancer and other diseases in which genes are inappropriately shut off.
- Bernstein Lab
Dr. Irwin D. Bernstein's research interests include normal and leukemic hematopoietic stem cells, antibody targeted therapies for lymphoma and leukemia, and the biology of acute myeloid leukemia.
- Biobehavioral Sciences
The Biobehavioral Sciences program investigates mechanisms and methods for integrating behavioral and biological components of care for cancer survivors during and following active treatment.
- Clurman Lab
The Clurman Lab studies how cell division is regulated in normal cells, and how abnormal control of cell division leads to cancer. They hope to use these mechanistic insights into tumor formation to develop new cancer treatment strategies.
- Crohn's Allogeneic Transplant Study (CATS)
A clinical study for treatment of patients with severe Crohn's Disease, using bone marrow transplantation. This study is being conducted by Dr. George McDonald and teams of doctors and nurses at the University of Washington Medical Center, Seattle Children's Hospital and the Fred Hutchinson Cancer Research Center in Seattle.
- defeatHIV, the Delaney Cell and Genome Engineering Initiative
Led by the Hutchinson Center's Drs. Keith Jerome and Hans-Peter Kiem, the Delaney Cell and Genome Engineering Initiative, also known as defeatHIV, is a consortium of FHCRC and external investigators working together to eradicate HIV. Their research efforts utilize the latest cellular and genetic engineering techniques to develop HIV-resistant cells and to target and incapacitate HIV within the host.
- Delaney Lab
- Fero Lab
The Fero Lab studies how cell-cycle regulatory genes, p27 and Rb, control growth of tumors and normal tissues. Using novel mouse models and genomic technologies, they have discovered that cell cycle inhibitors and microRNAs regulate T-cell growth and differentiation, whereas mutations of these genes cooperate in lymphoma development.
- Geballe Lab
The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses.
- Green Group
- Greenberg Lab
The Greenberg Lab's guiding research goals are to understand the principles underlying T cell recognition of viruses and cancer cells, to determine why such responses often fail to eliminate the virus or cancer, and to develop cellular and molecular approaches that manipulate the immune system to treat human viral and malignant diseases.
- GVHD Assessment Video
- Hansen Lab
The Hansen Lab's primary research focus is graft-vs.-host disease (GVHD). Ongoing studies investigate whether monitoring of gene expression correlates with T-cell activation, programmed cell death, severity of GVHD, the patient���s response to primary therapy or treatment failure, and emergence of tolerance.
- Heimfeld Lab
The Heimfeld Lab focuses on the translation of new cell-based therapies from the scientist's bench to the patient's bedside. Areas of research include improvements in specific cell-subset selection, large-scale therapeutic-cell culturing in closed systems, optimized cryopreservation and cell storage.
- Hockenbery Lab
The Hockenbery lab studies programmed cell death (apoptosis) pathways that are defective in many cancer cells; and the role of cancer-cell metabolism in apoptosis, oncogene functions, and environmental/dietary risk factors, including excess supply of nutrients. After identifying cancer-selective targets, they carry out small-molecule screens for inhibitors to identify lead compounds as anticancer agents.
- Institute for Prostate Cancer Research
The institute is a collaborative effort of Fred Hutchinson Cancer Research Center and UW Medicine. A natural outgrowth of established research and clinical collaborations, the IPCR brings together a world-renowned team whose mission is to understand the causes of prostate cancer and its progression, develop new prevention strategies, devise innovative diagnostics and improve survival and quality of life.
- Kiem Lab
The Kiem Lab studies stem cell biology and stem cell gene transfer with the goal of developing new treatment strategies for patients with genetic and infectious diseases and cancers.
- Lee Lab
- Long-Term Follow-Up
- Lymphoma Program
- Mendez Lab
- Nelson Lab
The J. Lee Nelson Lab studies microchimerism, a natural state in which cells are exchanged between mother and fetus during pregnancy and can remain in the other individual decades later. They study the role of this phenomenon in autoimmune diseases, pregnancy complications and cancer, as well as its impact on the success of blood stem-cell and organ transplants.
- Oehler Lab
- Olson Lab
The Olson Lab studies pediatric brain tumors, brain development and neurodegenerative disorders. The lab has a strong focus on emergent technologies such as "tumor paint," which causes cancer cells to glow with light so that surgeons can see them during an operation.
- Pagel Lab
The Pagel lab focuses on the development and improvement of antibody therapies for leukemia and lymphoma, with the goal of decreasing toxic side effects while increasing the treatment's effectiveness. Our projects focus on advancing radioimmunotherapy through a pre-targeted method of delivering radiation to tumor sites.
- Paulovich Lab
The Paulovich Lab works to characterize human variation and to relate this variation to clinically relevant endpoints, such as predicting a patient's risk of cancer and tolerance for treatments. Projects range from studying cellular DNA damage response in yeast and mammalian cells, to developing novel mass spectrometry-based technologies for finding and validating new protein biomarkers to serve as diagnostic tests.
- Press Lab
Dr. Press is a pioneer in immunotherapy, a treatment strategy that harnesses the power of the immune system. His lab engineers antibodies that help to destroy cells involved in blood cancers and carry radiation directly to cancer cells. They also genetically modify disease-fighting T-cells to boost their ability to recognize and kill lymphoma cells.
- Puget Sound Oncology Consortium
Secure member site for the Puget Sound Oncology Consortium (PSOC) - a non-profit corporation located at the Fred Hutchinson Cancer Research Center. Physicians in the Puget Sound area established PSOC in 1983 to conduct and promote clinical trials.
- Radich Lab
The Radich Lab studies the molecular genetics of response, progression and relapse in human leukemia. Research topics include the detection of minimal residual disease, the role of signal transduction abnormalities in leukemia, and the construction of gene-expression profiles of response and progression.
- Research Cell Bank
The Research Cell Bank (RCB) is a qualified, experienced research facility that has been actively engaged in clinical research through B-lymphoblastoid cell (B-LCL) transformation and maintenance, DNA extraction, and inventory control for more than 30 years. The RCB is currently expanding its role as a core repository of reagents and services to better serve the needs of investigators worldwide.
- Shimamura Lab
The Shimamura Lab works to understand the molecular mechanisms contributing to development of blood cells (hematopoiesis) and cancer (tumorigenesis), with the ultimate goal of informing rationally designed therapeutic strategies. Their research focuses particularly on genetic marrow failure syndromes.
- Simon Lab
The overarching goal of the projects in the Simon laboratory is the development of small molecules as mechanistic probes for a variety of cellular processes and as potential lead compounds for the development of therapeutic agents. To this end we apply an interdisciplinary approach ranging from chemical synthesis and medicinal chemistry to genetics and cell biology. The compounds we are studying have been identified from large collections of synthetic, drug-like compounds and from natural sources. While screening compound libraries is a significant part of what we do the majority of our efforts go into mechanistic studies to understand the biology and pharmacology of lead compounds and efforts to improve their activity through chemical synthesis of analogs.
- Spies Lab
The Spies Lab focuses on experimental studies of the human NKG2D lymphocyte receptor and its ligands, and the mechanisms whereby these proteins stimulate or suppress immune responses against cancer and in autoimmune disease.
- Stirewalt Lab
The Stirewalt Lab is using AML as a prototype to explore the relationship of aging and malignant transformation, and how aging may be changing the biology of the hematopoietic diseases in older adults.
- Storb Lab
Transplantation Biology combines basic and translational research directed at understanding and eliminating major barriers to successful allogeneic hematopoietic stem cell transplantation; these include host-versus-graft reactions, graft failure, acute and chronic graft-versus-host disease (GVHD), regimen-related toxicities, and induction of graft-versus-tumor reactions. The program’s goal has been to use stem cell transplantation to treat patients with malignant and nonmalignant hematologic diseases.
- Survivorship Program
Fred Hutchinson Cancer Research Center's Survivorship Program offers support, treatment and education to cancer survivors.
A member of the LIVESTRONG Survivorship Center of Excellence Network, the Survivorship Program is helping to lead a nationwide effort to help survivors and their healthcare providers understand, prevent and manage the medical and psychosocial effects of having cancer and receiving treatment.
- Tapscott Lab
The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.
- Tumor Vaccine Group
- Walter Lab
Research is focused on clinical trials testing new drugs and drug combinations to treat acute myeloid leukemia.
- Warren Lab
The Warren Lab studies human antitumor immune responses at the cellular and molecular level in order to learn how these immune responses can be exploited to treat human cancer.