Clinical Research Division
- Bedalov Lab
The Bedalov Lab conducts research to identify drugs that disrupt gene silencing, a process that has been implicated in cancer and other diseases in which genes are inappropriately shut off.
- Bernstein Lab
Dr. Irwin D. Bernstein's research interests include normal and leukemic hematopoietic stem cells, antibody targeted therapies for lymphoma and leukemia, and the biology of acute myeloid leukemia.
- Biobehavioral Sciences
The Biobehavioral Sciences program investigates mechanisms and methods for integrating behavioral and biological components of care for cancer survivors during and following active treatment.
- Clurman Lab
The Clurman Lab studies how cell division is regulated in normal cells, and how abnormal control of cell division leads to cancer. They hope to use these mechanistic insights into tumor formation to develop new cancer treatment strategies.
- Crohn's Allogeneic Transplant Study (CATS)
A clinical study for treatment of patients with severe Crohn's Disease, using bone marrow transplantation. This study is being conducted by Dr. George McDonald and teams of doctors and nurses at the University of Washington Medical Center, Seattle Children's Hospital and the Fred Hutchinson Cancer Research Center in Seattle.
- Delaney Lab
The focus of the Delaney Lab is the development and clinical translation of methodologies for the ex vivo expansion of hematopoietic stem and progenitor cells. In particular, cord blood stem and progenitor cells with the goal of improving outcomes for patients undergoing cord blood transplantation.
- Fero Lab
The Fero Lab studies how cell-cycle regulatory genes, p27 and Rb, control growth of tumors and normal tissues. Using novel mouse models and genomic technologies, they have discovered that cell cycle inhibitors and microRNAs regulate T-cell growth and differentiation, whereas mutations of these genes cooperate in lymphoma development.
- Green Group
- Greenberg Lab
The Greenberg Lab's guiding research goals are to understand the principles underlying T cell recognition of viruses and cancer cells, to determine why such responses often fail to eliminate the virus or cancer, and to develop cellular and molecular approaches that manipulate the immune system to treat human viral and malignant diseases.
- GVHD Assessment Video
- Hansen Lab
The Hansen Lab's primary research focus is graft-vs.-host disease (GVHD). Ongoing studies investigate whether monitoring of gene expression correlates with T-cell activation, programmed cell death, severity of GVHD, the patient���s response to primary therapy or treatment failure, and emergence of tolerance.
- Heimfeld Lab
The Heimfeld Lab focuses on the translation of new cell-based therapies from the scientist's bench to the patient's bedside. Areas of research include improvements in specific cell-subset selection, large-scale therapeutic-cell culturing in closed systems, optimized cryopreservation and cell storage.
- Immunology Study
Fred Hutch is recruiting volunteers for a study focused on the development of new immunotherapy-based treatment. Study volunteers will go through a screening process to determine eligibility. Eligible donors are added to our database for study enrollment. Eligible donors will be invited to attend a blood draw donation event.
- Institute for Prostate Cancer Research
The institute is a collaborative effort of Fred Hutchinson Cancer Research Center and UW Medicine. A natural outgrowth of established research and clinical collaborations, the IPCR brings together a world-renowned team whose mission is to understand the causes of prostate cancer and its progression, develop new prevention strategies, devise innovative diagnostics and improve survival and quality of life.
- Kiem Lab
The Kiem Lab studies stem cell biology and stem cell gene transfer with the goal of developing new treatment strategies for patients with genetic and infectious diseases and cancers.
- Lee Lab
Our work focuses on hematopoietic stem cell transplant patients and chronic graft-versus-host disease (cGHVD). Dr. Lee is the lead investigator and Fred Hutchinson Cancer Research Center is the coordinating center for the Chronic Graft-versus-Host Disease Consortium within the Rare Diseases Clinical Research Network.
- Long-Term Follow-Up
- Lymphoma Program
- Mendez Lab
Our research is looking to discover which genes are related specifically to the spread of head and neck cancers to other parts of the body by comparing the genetics of tumors that have not spread with those that have. We hope to one day allow physicians to predict which tumors are more likely to spread, information that will, in turn, affect treatment decisions.
- Nelson Lab
The J. Lee Nelson Lab studies microchimerism, a natural state in which cells are exchanged between mother and fetus during pregnancy and can remain in the other individual decades later. They study the role of this phenomenon in autoimmune diseases, pregnancy complications and cancer, as well as its impact on the success of blood stem-cell and organ transplants.
- Oehler Lab
- Olson Lab
The Olson Lab studies pediatric brain tumors, brain development and neurodegenerative disorders. The lab has a strong focus on emergent technologies such as "tumor paint," which causes cancer cells to glow with light so that surgeons can see them during an operation.
- Pagel Lab
The Pagel lab focuses on the development and improvement of antibody therapies for leukemia and lymphoma, with the goal of decreasing toxic side effects while increasing the treatment's effectiveness. Our projects focus on advancing radioimmunotherapy through a pre-targeted method of delivering radiation to tumor sites.
- Paulovich Lab
The Paulovich Lab works to characterize human variation and to relate this variation to clinically relevant endpoints, such as predicting a patient's risk of cancer and tolerance for treatments. Projects range from studying cellular DNA damage response in yeast and mammalian cells, to developing novel mass spectrometry-based technologies for finding and validating new protein biomarkers to serve as diagnostic tests.
- Press Lab
Dr. Press is a pioneer in immunotherapy, a treatment strategy that harnesses the power of the immune system. His lab engineers antibodies that help to destroy cells involved in blood cancers and carry radiation directly to cancer cells. They also genetically modify disease-fighting T-cells to boost their ability to recognize and kill lymphoma cells.
- Puget Sound Oncology Consortium
Secure member site for the Puget Sound Oncology Consortium (PSOC) - a non-profit corporation located at the Fred Hutchinson Cancer Research Center. Physicians in the Puget Sound area established PSOC in 1983 to conduct and promote clinical trials.
- Radich Lab
The Radich Lab studies the molecular genetics of response, progression and relapse in human leukemia. Research topics include the detection of minimal residual disease, the role of signal transduction abnormalities in leukemia, and the construction of gene-expression profiles of response and progression.
- Research Cell Bank
The Research Cell Bank (RCB) is a qualified, experienced research facility that has been actively engaged in clinical research through B-lymphoblastoid cell (B-LCL) transformation and maintenance, DNA extraction, and inventory control for more than 30 years. The RCB is currently expanding its role as a core repository of reagents and services to better serve the needs of investigators worldwide.
- Shimamura Lab
The Shimamura Lab works to understand the molecular mechanisms contributing to development of blood cells (hematopoiesis) and cancer (tumorigenesis), with the ultimate goal of informing rationally designed therapeutic strategies. Their research focuses particularly on genetic marrow failure syndromes.
- Spies Lab
The Spies Lab focuses on experimental studies of the human NKG2D lymphocyte receptor and its ligands, and the mechanisms whereby these proteins stimulate or suppress immune responses against cancer and in autoimmune disease.
- Stirewalt Lab
The Stirewalt Lab is using AML as a prototype to explore the relationship of aging and malignant transformation, and how aging may be changing the biology of the hematopoietic diseases in older adults.
- Storb Lab
Transplantation Biology combines basic and translational research directed at understanding and eliminating major barriers to successful allogeneic hematopoietic stem cell transplantation; these include host-versus-graft reactions, graft failure, acute and chronic graft-versus-host disease (GVHD), regimen-related toxicities, and induction of graft-versus-tumor reactions. The program’s goal has been to use stem cell transplantation to treat patients with malignant and nonmalignant hematologic diseases.
- Survivorship Program
Fred Hutchinson Cancer Research Center's Survivorship Program offers support, treatment and education to cancer survivors.
A member of the LIVESTRONG Survivorship Center of Excellence Network, the Survivorship Program is helping to lead a nationwide effort to help survivors and their healthcare providers understand, prevent and manage the medical and psychosocial effects of having cancer and receiving treatment.
- Tumor Vaccine Group
- Walter Lab
Research is focused on clinical trials testing new drugs and drug combinations to treat acute myeloid leukemia.
- Warren Lab
The Warren Lab studies human antitumor immune responses at the cellular and molecular level in order to learn how these immune responses can be exploited to treat human cancer.