The Division of Basic Sciences at Fred Hutch was founded in 1981 with the goal of providing a unique and exciting environment to foster creative and ground-breaking research. The Division maintains an egalitarian philosophy that promotes stimulating and creative science. The Division's emphasis on scientific excellence, collegiality and interactivity has led to many important scientific advances. These include key discoveries related to the molecular basis of differentiation, epigenetic and genetic controls of gene transcription, mechanisms of signal transduction, regulation of the cell cycle, molecular controls over HIV and other viruses, the structural basis for RNA and DNA enzymes and regulation of developmental processes. The Division consists of ~30 laboratories that investigate the cellular and molecular mechanisms behind disease and the operations of complex systems. This fundamental understanding of how biology works leads to discoveries and better therapeutic interventions. Our scientists often take existing knowledge and link it in new ways- behind every breakthrough are basic discoveries.