Thomas L. Vaughan, M.D., M.P.H.

faculty member

Thomas L. Vaughan, M.D., M.P.H.

Member
Public Health Sciences Division, Fred Hutch

Fax: 206.667.4787
Mailstop: M4-B874

Dr. Thomas Vaughan investigates environmental and host factors that contribute to the risk of cancers of the upper gastrointestinal tract and respiratory system, as well as factors that influence survival. His major concentration is the identification of medical, lifestyle and genetic factors that underlie the dramatic increase in incidence of adenocarcinomas arising in the esophagus and gastric cardia over the past several decades. He does this through population-based case-control studies of cancer, community-based case-control studies of the key precancerous lesion, Barrett’s esophagus, and a long-standing cohort study of persons with Barrett’s. He is investigating determinants of genetic susceptibility in genome-wide association studies, also known as GWAS, in collaboration with the international BEACON consortium and others. He also seeks to identify potential preventive measures for these cancers, such as use of anti-inflammatory medications. Recently he has focused on translating findings from observational studies and trials to the clinical and population settings. Dr. Vaughan and his colleagues have advanced a detailed research roadmap to overcome the limitations inherent in current approaches to controlling esophageal adenocarcinoma, and they created a web-based risk calculator and information resource called IC-RISC to inform shared decision-making between a health provider and patient regarding screening, surveillance and treatment options.

Other Appointments & Affiliations

Professor Emeritus, Epidemiology
University of Washington School of Public Health and Community Medicine

Education

M.P.H., University of Washington, 1983

M.D., University of Illinois, 1978

B.S., Biomedical Engineering, Cornell University, 1974

Find A Clinical Trial

Dr. Vaughan in the News

Sorting out the truth about aspirin

Hutch News - June 27, 2014

Quantifying biomarker risks and benefits

Science Spotlight - April 21, 2014

For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email media@fredhutch.org or call 206.667.2210