Clinical Research Division, Fred Hutch
Dr. Mary Flowers leads a team at Fred Hutch and its clinical-care partner, Seattle Cancer Care Alliance, that supports bone marrow and stem cell transplant survivors long after they finish initial treatment. She is a world-renowned expert in the study and treatment of chronic graft-vs-host disease, or cGVHD, a complication of transplantation in which the donated stem cells attack the recipient's healthy tissues. As director of the world-class post-transplant Adult Clinical Care Long-Term Follow-Up Program, known as the LTFU, Dr. Flowers and colleagues help transplant survivors and their primary care physicians manage post-treatment complications as patients recover and resume their lives. The LTFU also serves as a model for the training of transplant physicians, as does the Fred Hutch chronic GVHD training program, which attracts hematology/oncology fellows and visiting physicians from transplant programs across the U.S. and in more than 12 countries. In addition to her GVHD research, Dr. Flowers studies the effectiveness of using donated lymphocytes, a type of immune cell, to treat recurrent malignancies after transplantation with donated cells.
Management of chronic GVHD and other late effects of hematopoietic cell transplantation.
Professor, Division of Medical Oncology, Department of Medicine
University of Washington
Medical Director, Long-Term Follow-Up Clinic
Seattle Cancer Care Alliance
Director at Large
American Society for Transplantation and Cellular Therapy (ASTCT) Executive Committee
Brazil/Seattle Chronic GVHD Consortium
Brazilian Society of BMT Chronic GVHD and Late Effects Working Group
National Institute of Health (NIH) Chronic GVHD Diagnosis and Staging Working Group
Center for International Blood & Marrow Transplant Research (CIBMTR) Working Committee for Late Effects and Quality of Life
ASTCT and CIBMTR Scientific Organizing Committee
M.D., Centro de Ciencias da Saude da Universadiade Federal do Rio Grande do Norte, Natal, R.N., Brasil
Board Certified in Hematology, Pontifícia Universidade Catolica do Rio de Janeiro, Rio de Janeiro, R.J., Brazil
Dr. Flowers’ clinical research has focused on long-term outcomes after hematopoietic cell transplantation (HCT), with particular attention to studies of chronic graft-versus-host disease (GVHD), quality of life and other late events. Her research has spanned the gamut from clinical trials to registry studies to cohort studies. She has been the principal investigator or co-investigator in several interventional clinical trials including multicenter randomized studies in chronic GVHD.
Study Number: 9896
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