"Phospho-regulation of chromosome segregation by the conserved kinase Mps1"
Defective segregation of chromosomes during cell division causes aneuploidy and is a characteristic feature of cancer cells. Cells therefore utilize multiple mechanisms to ensure faithful segregation and prevent aneuploidy, including phospho-regulation of proteins responsible for separating replicated chromosomes during mitosis. These mechanisms depend on the essential, conserved protein kinase Mps1. The goal of my work is to identify the downstream effectors of Mps1 in chromosome segregation and to illuminate the mechanisms of Mps1 function. This work will combine novel biochemical and cell biological approaches with emerging structural analysis methods to improve fundamental understanding of phospho-regulation of chromosome segregation.