Interdisciplinary Training

Mette Peters

Analysis of Prostate Cancer Susceptibility Genes

Approximately 41,000 men die of prostate cancer each year, which is similar to the yearly death rate of women from breast cancer. Segregation analysis studies indicate that strong familial components are involved in the etiology of prostate cancer, particularly in families with several afflicted members or families with an early onset of the disease. The aim of my study is to identify regions of the genome that may contain prostate cancer susceptibility genes. This research is based on a collaboration between Dr. Elaine Ostrander (Clinical Science Division) and Dr. Janet Stanford (Public Health Sciences Division). A large-scale ongoing effort, coordinated by Dr. Janet Stanford, has taken place to collect epidemiological information and DNA from high-risk prostate cancer families. DNA samples from these families have been distributed in part to the Ostrander laboratory for genotyping and linkage analysis. To date I have been involved in a 10cM genome-wide scan of 94 of these prostate cancer families which has identified several potential prostate cancer susceptibility regions. I have also analyzed 186 of our prostate cancer families for linkage to a putative prostate cancer susceptibility region at Xq27-28. Although this analysis did not show statistically significant evidence to the linkage of prostate cancer susceptibility to Xq27-28, the results were consistent with a small percentage of our families being linked to this region.

Peters, M.A., G.P Jarvik, M. Janer, L. Chakrabarti, S. Kolb, E.L Goode, M. Gibbs, C.C DuBois, E.F Schuster, L. Hood, E.A Ostrander, and J.L Stanford. 2000. Genetic linkage analysis of prostate cancer families to Xq27-28. Human Heredity. In press.