Dr Nghiem is a cancer biologist with an interest in signal transduction, cell cycle checkpoints, and immunology (see www.pnlab.org). He also trained as a dermatologist, and cares for patients with skin cancers that are typically induced by environmental exposure to ultraviolet radiation. A major focus in his lab is a UV- and polyomavirus-associated skin cancer called Merkel cell carcinoma (MCC, see www.merkelcell.org). The reported incidence of this cancer has quadrupled in the past 2 decades, and its associated mortality is nearly 3 times higher than malignant melanoma. Polyomavirus protein expression is required for its continued growth, and it is strongly linked to T cell immune dysfunction, making it potentially amenable for rational immunotherapy, a significant area of interest in Dr Nghiem's lab.