Graduate Students

Courses Offered at Fred Hutch

AUTUMN 2014

Conj 533  
The Dynamic Chromosome (1.5 Credits)
Autumn 2014 — Weeks 1-5 (09/25/14-10/28/14)

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizer: Steven Henikoff (FHCRC/UW Genome Science Affiliate)

This course is a graduate level introduction to the chromosome, viewing it as the ultimate organelle. Topics this year will focus on the functions and evolution of chromosomal elements as well as the mechanisms that ensure the maintenance and propagation of chromosomes. The class will use a combination of lecture, literature review, and in class discussion to explore genetic, biochemical, and cytological methods for defining our current knowledge about chromosomes. The course requires students to have taken undergraduate cell biology, biochemistry and genetics. Active participation in discussion is required.

*For more information about the course contact Steve Henikoff, (206) 667-4515

Conj 533 Course website

Conj 537
Mechanisms of Transcriptional Regulation (1.5 Credits)
Autumn 2014 - Weeks 6-10 (10/30/14-12/04/14)

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizer: Toshio Tsukiyama (FHCRC/UW Biochemistry Affiliate)

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Transcriptional regulation, development and diseases in mammals (Steve Tapscott).

For more information about the course contact Toshio Tsukiyama, (206) 667-4996

Conj 537 Course website

WINTER 2015

Conj 544 
Protein Structure, Modification and Regulation (1.5 Credits)
Winter 2015 — Weeks 1-5 (01/06/15-02/05/15)

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: Barry Stoddard (FHCRC/UW Biochemistry Affiliate)
Readings: Selected papers from primary literature.

We will provide an overview of general principles of protein structure and function, including (i) forces and interactions that contribute to folding, dynamics and stability, (ii) the diversification of protein fold and function during evolution; (iii) the functional implications of progression from single domain to multi-domain structures; (iii) modular repeat proteins; and (iv) principles of protein-ligand binding.  A key goal of the class is to introduce students to the best practice and use of common protein visualization and analysis tools, including the Protein Structural Database, PyMol, fold-prediction servers and homology modeling servers and algorithms.

Background and Prerequisites: The course will assume knowledge at the level of an advanced undergraduate biochemistry course.  Knowledge in the areas we will discuss at the level of Stryer Biochemistry or Alberts Molecular Biology of the Cell  will be assumed.

For More Information and Course Overview

MCB 515 
MCB Literature Review (2 non-graded Credits)
Winter 2015 (01/07/15-03/11/15)

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Wednesdays, 4:00-5:20
Instructors: Katie Peichel (FHCRC/UW Biology Affiliate), Rich Gardner (UW Pharmacology Department)

For more information contact Katie Peichel, (206) 667-1628

MCB 515 Course Website

SPRING 2015

MCB 539 
Biological Basis of Neoplasia (3 Credits)
Spring 2015 (03/31/15-06/04/15)

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: Valeri Vasioukhin (FHCRC/UW Pathology Affiliate), Toshiyasu Taniguchi, (FHCRC/UW Pathology Affiliate)

This course allows students to gain experience in applying the several disciplines which comprise cellular and molecular biology toward a deeper understanding of a complex biological problem: neoplastic change. The course consists of a series of lectures and discussion meetings to introduce students to the major themes in research in the cellular and molecular biology of neoplastic change. They cover principal molecular mechanisms responsible for tumor initiation and progression, with a specific emphasis on DNA repair mechanisms, cell cycle checkpoints and loss of normal tissue homeostasis. The latest state of the art research in  Cancer Biology will be presented by invited scientists experts in their relevant field.  The discussion meetings will concentrate on selected major papers in cancer biology and be presented and discussed by the students with help and guidance of the instructors.  

Student overall participation, activity during discussions, quality and depth of the research paper presentation, and the written research proposal on one of the topics in cancer biology will be used for course credit and grading.

Prerequisites: Introductory biochemistry and cell biology.

For more information contact: Toshiyasu Taniguchi  (206) 667-4996 or Valeri Vasioukhin, (206) 667-1710

MCB 539 Course website

MCB / FHCRC 533 
Evolutionary Genetics and Genomics (3 Credits)
Spring 2015 (03/31/15-06/04/15)

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 1:30 - 3:00
Instructors: *Katie Peichel (FHCRC/UW Biology Affiliate), Harmit Malik, (FHCRC/UW Genome Sciences Affiliate)

An understanding of evolutionary processes is becoming increasingly important in biomedical research. The purpose of this elective is to introduce graduate students with backgrounds in molecular, cellular, and developmental biology to evolutionary approaches. A combination of lectures, discussions of primary literature, and "hands-on" assignments to provide training in comparative and genomic approaches will be used during the course. Tuesdays and Thursdays from 1:30 to 3:00 PM.; FHCRC Rooms B1-072 & 074. Course registration is limited to 15.

*For more information contact Katie Peichel, (206) 667-1628

MCB 533 Course website

MCB 516 
MCB Literature Review (2 non-graded Credits)
Spring 2015 (01/07/15-03/11/15)

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Wednesdays, 4:00-5:20
Instructors: Katie Peichel (FHCRC/UW Biology Affiliate), Rich Gardner (UW Pharmacology Department)

For more information contact Katie Peichel, (206) 667-1628

MCB 516 Course Website

AUTUMN 2016

MCB / FHCRC 532  
Human Pathogenic Viruses (3 Credits)
Autumn 2015

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 1:30 - 3:00
Instructor: Michael Emerman (FHCRC/UW Microbiology Affiliate)

This course will cover the molecular biology and pathogenesis of major groups of human viruses, including retroviruses, flaviviruses, herpesviruses, influenza viruses, poliovirus, papillomaviruses, and others. The class will meet on Tuesdays and Thursdays from 1:30 to 3:00 PM.; FHCRC Rooms B1-072 & 074. Course registration is limited to 24.

For more information contact Michael Emerman, (206) 667-5058.

MCB 532 Course website

MCB / FHCRC 522
Developmental Basis of Human Disease
(3 Credits)
Autumn 2015  

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/74
Meeting Time: TBD
Instructors: Cecilia Moens (FHCRC/UW Biology Affiliate)

This ten-week course will explore the intimate relationship between human genetic disease and developmental biology. Each week we will choose a different human disorder whose genetic basis has been recently discovered, and we will discuss how the same genes regulate key processes in animal development. The second meeting of each week will be an opportunity for students to present recent papers from the literature relating to these developmental processes. We will end each week by formulating hypotheses about how mutations in these developmental control genes may cause the human disease in which they have been implicated.

MCB 522 Course website

For more information, contact Cecilia Moens, (206) 667-5627

Conj 552
Metabolic Flexibility in Biology
(1.5 Credits)
Autumn 2015 — Weeks 1-5

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/74
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: Dan Gottschling (FHCRC/UW Genome Sciences Affiliate), Mark Roth (FHCRC/UW Biochemistry Affiliate)

This course will focus on small molecules and the ways that the chemistry of these molecules facilitates life under changing conditions. It will include systems from microbiology to human physiology to understand aspects of cancer, aging, and animation. A combination of lecture and in class discussion will be used to explore topics including bioenergetics/metabolic flux, adaptation, and allometric scaling.

Prerequisites: Undergraduate organic chemistry and biochemistry. Evaluations will be made based on assigned problem sets. Graduate students only. No auditors. Course limited to 25 students.

For more information about the course contact Dan Gottschling, (206) 667-4494

Conj 552 Course website

Conj 537
Mechanisms of Transcriptional Regulation (1.5 Credits)
Autumn 2015 - Weeks 6-10

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizer: Toshio Tsukiyama (FHCRC/UW Biochemistry Affiliate)

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Transcriptional regulation, development and diseases in mammals (Steve Tapscott).

For more information about the course contact Toshio Tsukiyama, (206) 667-4996

Conj 537 Course website

WINTER 2016

Conj 512 
How To Give A Scientific Seminar (1.5 Credits)
Winter 2016 — Weeks 1-5

Location: FHCRC, Day Campus; Weintraub Bldg., Rm. B1-076
Meeting Time: Tues & Thurs, 3:20 to 4:40p
Organizers: *Sue Biggins (FHCRC/UW Biochemistry Affiliate), Jihong Bai (FHCRC/UW Biochemistry Affiliate)

This course will provide training for MCB graduate students to effectively give a scientific seminar about their research. At the end of the class, students will have prepared and practiced a complete seminar and received feedback from their peers and the instructors.

*For more information about the course contact Sue Biggins, (206) 667-1351

Conj 512 Course description

Conj 544 
Protein Structure, Modification and Regulation (1.5 Credits)
Winter 2016 — Weeks 1-5  

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: Roland Strong (FHCRC/UW Immunology Affiliate)
Readings: Selected papers from primary literature.

We will provide an overview of general principles of protein structure and function, including (i) forces and interactions that contribute to folding, dynamics and stability, (ii) the diversification of protein fold and function during evolution; (iii) the functional implications of progression from single domain to multi-domain structures; (iii) modular repeat proteins; and (iv) principles of protein-ligand binding.  A key goal of the class is to introduce students to the best practice and use of common protein visualization and analysis tools, including the Protein Structural Database, PyMol, fold-prediction servers and homology modeling servers and algorithms.

Background and Prerequisites: The course will assume knowledge at the level of an advanced undergraduate biochemistry course.  Knowledge in the areas we will discuss at the level of Stryer Biochemistry or Alberts Molecular Biology of the Cell  will be assumed.

For More Information and Course Overview

Conj 529 
Cell Migration (1.5 Credits)
Winter 2016 — Weeks 6-10

Location: FHCRC, Day Campus; Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizers: *Cecilia Moens (FHCRC/UW Biology & BMSD Affiliate), Jon Cooper (FHCRC/UW Biochemistry Affiliate)

This course will explore mechanisms of cell migration in vivo and in cell culture. We will discuss the cell biology of different forms of cell migration, the extracellular cues that direct migration and how these cues are integrated by the migrating cell.

*For more information about the course contact Cecilia Moens, (206) 667-5627

Conj 529 Course website

MCB 515 
MCB Literature Review (2 non-graded Credits)
Winter 2015 (01/07/15-03/11/15)

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Wednesdays, 4:00-5:20
Instructors: Katie Peichel (FHCRC/UW Biology Affiliate), Rich Gardner (UW Pharmacology Department)

For more information contact Katie Peichel, (206) 667-1628

MCB 515 Course Website

SPRING 2016

MCB 539 
Biological Basis of Neoplasia (3 Credits)
Spring 2016

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: Valeri Vasioukhin (FHCRC/UW Pathology Affiliate), Toshiyasu Taniguchi, (FHCRC/UW Pathology Affiliate)

This course allows students to gain experience in applying the several disciplines which comprise cellular and molecular biology toward a deeper understanding of a complex biological problem: neoplastic change. The course consists of a series of lectures and discussion meetings to introduce students to the major themes in research in the cellular and molecular biology of neoplastic change. They cover principal molecular mechanisms responsible for tumor initiation and progression, with a specific emphasis on DNA repair mechanisms, cell cycle checkpoints and loss of normal tissue homeostasis. The latest state of the art research in  Cancer Biology will be presented by invited scientists experts in their relevant field.  The discussion meetings will concentrate on selected major papers in cancer biology and be presented and discussed by the students with help and guidance of the instructors.  

Student overall participation, activity during discussions, quality and depth of the research paper presentation, and the written research proposal on one of the topics in cancer biology will be used for course credit and grading.

Prerequisites: Introductory biochemistry and cell biology.

For more information contact: Toshiyasu Taniguchi  (206) 667-4996 or Valeri Vasioukhin, (206) 667-1710

MCB 539 Course website

MCB 516 
MCB Literature Review (2 non-graded Credits)
Spring 2016

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Wednesdays, 4:00-5:20
Instructors: Katie Peichel (FHCRC/UW Biology Affiliate), Rich Gardner (UW Pharmacology Department)

For more information contact Katie Peichel, (206) 667-1628

MCB 516 Course Website