Pioneering bone marrow transplantation – Led by Nobel Prize recipient Dr. E. Donnall Thomas, Fred Hutch researchers have transformed bone marrow transplantation into standard treatment for leukemia and other blood cancers. The procedure is widely recognized as one of the greatest achievements in cancer treatment and has saved the lives of hundreds of thousands of patients. Learn more >
Making transplantation less toxic – Dr. David Maloney has been leading clinical trials that investigate how combining lower-intensity radiation conditioning with an infusion of donated stem cells can effectively treat CLL patients.
Developing targeted therapies – Dr. John Pagel has been investigating a treatment technique called radioimmunotherapy, which uses an antibody—known by the trade name Bexxar—to deliver a small, targeted dose of radiation to CLL cells. Because the antibody is able to bind to an antigen associated specifically with the cancer, this technique limits damage to the surrounding normal, healthy tissues.
Investigating new drug combinations – Clinical trials led by Dr. Pagel are evaluating the safety and effectiveness of Bexxar in combination with more traditional chemotherapy, including Rituximab, another antibody-based drug developed thanks to pioneering work from Hutch researchers